90240
三醋酸甘油酯
≥99.0% (GC)
别名:
三醋精, 甘油三乙酸酯, 甘油三醋酸酯
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线性分子式:
(CH3COOCH2)2CHOCOCH3
化学文摘社编号:
分子量:
218.20
Beilstein:
1792353
EC 号:
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.25
质量水平
方案
≥99.0% (GC)
表单
liquid
环保替代产品特性
Less Hazardous Chemical Syntheses
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
折射率
n20/D 1.431
沸点
258-260 °C (lit.)
密度
1.158 g/mL at 20 °C
环保替代产品分类
脂质类型
saturated FAs
SMILES字符串
CC(=O)OCC(COC(C)=O)OC(C)=O
InChI
1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3
InChI key
URAYPUMNDPQOKB-UHFFFAOYSA-N
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一般描述
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product can replace highly toxic diluents in membrane preparation and thus aligns with "Less Hazardous Chemical Syntheses". Click here for more information.
应用
- 表观遗传启动靶向肿瘤异质性，将胰腺导管腺癌的转录组表型转变为维生素D易感状态。这项开创性研究利用三乙酸甘油酯作为表观遗传启动策略的一部分，使胰腺导管腺癌对维生素D敏感，这标志着癌症治疗方式的重大进步（He et al., 2024）。
- 三乙酸甘油酯可通过脂肪生成介导的IL-33促进小鼠缺血性卒中后血脑屏障恢复。：研究表明，三乙酸甘油酯能通过脂肪生成途径有效增强缺血性卒中后血脑屏障修复，为新的卒中恢复治疗提供了参考（Wei et al., 2023）。
- 基于纳米结构脂质载体的芹菜素给药策略开发研究：基于CCD-RSM的实验设计及NSCLC的体外评价：：本研究详细介绍了一种含有三乙酸甘油酯的纳米结构脂质载体的制备，该载体经优化可用于递送芹菜素以对抗非小细胞肺癌，强调了三乙酸甘油酯在靶向治疗应用中的潜力（Wang et al., 2023）。
- 新的邻苯二甲酸酯替代品是否比传统的DBP和DiBP更安全？使用体内、转录组和计算机方法对斑马鱼进行内分泌干扰比较分析。：本研究将三乙酸甘油酯作为传统邻苯二甲酸酯更安全的替代品，发现其内分泌干扰作用较低，这有助于更安全的工业和制药应用（Tan et al., 2023）。
- 饲喂三乙酸甘油酯会增加小鼠的血浆乙酸水平，但在急性电性癫痫模型中没有抗惊厥作用。：本研究评估了三乙酸甘油酯对血浆乙酸水平的生化影响，尽管在特定癫痫发作模型中没有抗惊厥作用，但为其代谢作用研究提供了宝贵数据（Xu et al., 2022）。
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
298.4 °F - closed cup
闪点(°C)
148 °C - closed cup
个人防护装备
Eyeshields, Gloves
Boyong Wan et al.
Analytica chimica acta, 681(1-2), 63-70 (2010-11-03)
Wavelet analysis is developed as a preprocessing tool for use in removing background information from near-infrared (near-IR) single-beam spectra before the construction of multivariate calibration models. Three data sets collected with three different near-IR spectrometers are investigated that involve the
G Sharma et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(2), 159-169 (2010-07-27)
Insulin loaded microemulsions were developed adopting a low shear reverse micellar approach using didoceyldimethylammonium bromide (DMAB) as the surfactant, propylene glycol (PG) as the co-surfactant, triacetin (TA) as the oil phase and insulin solution as the aqueous phase. A ternary
C N Madhavarao et al.
Journal of inherited metabolic disease, 32(5), 640-640 (2009-08-18)
Canavan disease (CD) is a fatal dysmyelinating genetic disorder associated with aspartoacylase deficiency, resulting in decreased brain acetate levels and reduced myelin lipid synthesis in the developing brain. Here we tested tolerability of a potent acetate precursor, glyceryl triacetate (GTA)
Shanhui Zhu et al.
Bioresource technology, 130, 45-51 (2013-01-12)
The synthesis of bioadditives for biofuels from glycerol esterification with acetic acid was performed over zirconia supported heteropolyacids catalysts using H(4)SiW(12)O(40) (HSiW), H(3)PW(12)O(40) (HPW) and H(3)PMo(12)O(40) (HPMo) as active compounds. The as-prepared catalysts were characterized by N(2)-physisorption, XRD, Raman spectroscopy
Hui Liu et al.
Journal of pharmaceutical sciences, 101(5), 1783-1793 (2012-02-10)
Although injectable depot-forming solutions have been commercialized, the factors that influence the overall release kinetics from such systems are still not fully understood. In this work, we address the effect of cosolvent on the issue of excessive burst release of
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