等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI
1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI key
CXOFVDLJLONNDW-UHFFFAOYSA-N
基因信息
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
一般描述
Phenytoin is an antiepileptic drug used in the prevention and treatment of seizures. This analytical reference standard is suitable as starting material for the preparation of calibrators and controls in phenytoin testing by GC/MS or LC-MS/MS. Phenytoin is sold under the trade name Dilantin®.
应用
- Advanced Separation and Extraction of Anticonvulsants: Phenytoin solution is utilized in the fabrication of surface molecularly imprinted polymer membranes. This innovative method enhances the separation and extraction of phenytoin, phenobarbital, and lamotrigine, significantly improving the precision and efficiency of drug monitoring in clinical and research settings (Zhao et al., 2024).
- LC-MS/MS Quantification for Drug Delivery: A sensitive LC-MS/MS method has been developed for the quantification of phenytoin and its major metabolite. This method is applied to both intravenous and intranasal delivery systems, enhancing our understanding of the pharmacokinetics and effectiveness of phenytoin as an anticonvulsant medication (Prentice et al., 2022).
- Clinical Decision Support for Pharmacogenomics: Phenytoin is involved in the appraisal and development of evidence-based clinical decision support systems. This research integrates pharmacogenomic data to optimize perioperative drug use, providing tailored therapeutic strategies based on genetic profiles, particularly for managing epilepsy treatments (Borden et al., 2021).
- Electromembrane Extraction Technique: The development of an electromembrane extraction method followed by capillary electrophoresis for phenytoin determination in exhaled breath condensate. This technique offers a non-invasive approach for therapeutic drug monitoring, critical for ensuring effective seizure control in epilepsy patients (Seyfinejad et al., 2020).
- Drug Crystallization Inhibition: Research into the use of polymer nanogels as reservoirs for phenytoin has shown potential in inhibiting drug crystallization. This approach could revolutionize drug delivery systems by maintaining the stability and bioavailability of phenytoin, enhancing its therapeutic efficacy for treating neurological disorders (Li et al., 2019).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilantin is a registered trademark of Warner-Lambert Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
WGK
WGK 2
闪点(°F)
49.5 °F
闪点(°C)
9.7 °C
法规信息
危险化学品
Elisa Colombo et al.
PloS one, 8(1), e55329-e55329 (2013-02-06)
The persistent Na⁺ current (I(NaP)) is important for neuronal functions and can play a role in several pathologies, although it is small compared to the transient Na⁺ current (I(NaT)). Notably, I(NaP) is not a real persistent current because it undergoes
B Medhi et al.
Indian journal of physiology and pharmacology, 56(4), 382-387 (2013-06-21)
Esomeprazole is commonly prescribed proton pump inhibitor for gastritis and peptic ulcer disease. Most of the time in clinical practice, phenytoin and esomeprazole are prescribed for patients of generalized seizures with concomitant peptic ulcer. Hence there are chances of drug-drug
Kimford J Meador et al.
The Lancet. Neurology, 12(3), 244-252 (2013-01-29)
Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age. In this
Bradley R Keel et al.
Tennessee medicine : journal of the Tennessee Medical Association, 106(4), 35-36 (2013-04-27)
Anticonvulsant Hypersensitivity Syndrome (AHS) is a rare complication of common drugs used today. It is unusual in that it occurs later than most other drug reactions, about two to six weeks after initiation of the offending agent. It also has
Amitava Dasgupta et al.
Journal of clinical laboratory analysis, 27(1), 1-4 (2013-01-18)
For many years, fluorescence polarization immunoassay (FPIA) on the TDx analyzer has been used for determination of free phenytoin concentration. Recently Abbott Laboratories decided to discontinue the TDx analyzer and related assays on this analyzer. Free phenytoin assay is also
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