等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in acetonitrile
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
NC(=O)N1c2ccccc2CC(=O)c3ccccc13
InChI
1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
InChI key
CTRLABGOLIVAIY-UHFFFAOYSA-N
基因信息
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
一般描述
Oxcarbazepine, marketed under the trade name Trileptal®, is an anticonvulsant developed and prescribed for treatment of epilepsy. In recent years, Oxcarbazepine has shown efficacy in treatment of mood disorders. This certified solution standard is suitable as starting material for the preparation of calibrators and controls in oxcarbazepine testing by GC/MS or LC-MS/MS.
应用
- Quantitative analysis for therapeutic monitoring: Oxcarbazepine solution is utilized in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the quantitative analysis of drug levels in patients undergoing epilepsy treatment. This approach aids in therapeutic drug monitoring, ensuring drug efficacy and safety (Johnson-Davis and Thomas, 2024).
- Advanced detection techniques: Research integrates Raman spectroscopy and convolutional neural networks for the detection of antiepileptic drug concentrations, including Oxcarbazepine. This technology enhances the precision of drug measurement, vital for managing and controlling seizures in neurological disorders (Fu et al., 2023).
- Environmental impact studies: Studies on the degradation of Oxcarbazepine by bromate in water under sunlight irradiation provide critical data on the environmental behavior of this pharmaceutical. Understanding its environmental breakdown helps in assessing the ecological impact and designing better waste management strategies (Sun et al., 2023).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Trileptal is a registered trademark of Novartis Corporation
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
WGK
WGK 2
闪点(°F)
35.6 °F
闪点(°C)
2 °C
法规信息
危险化学品
Gaetano Zaccara et al.
Seizure, 22(7), 528-536 (2013-04-30)
Analysis of overall tolerability and neurological adverse effects (AEs) of eslicarbazepine acetate (ESL), lacosamide (LCM) and oxcarbazepine (OXC) from double-blind, placebo-controlled trials. Indirect comparisons of patients withdrawing because of AEs, and the incidence of some vestibulocerebellar AEs between these three
Wassim Nasreddine et al.
Expert opinion on investigational drugs, 16(10), 1615-1625 (2007-10-10)
Neuropathic pain is a frequent condition that can result from a variety of underlying conditions and is frequently chronic and difficult to treat. A number of drugs are used to treat neuropathic pain, including anticonvulsants and antidepressants. Oxcarbazepine, a recently
[The use of oxcarbazepine (trileptal) in young epileptic women].
P N Vlasov et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 109(6), 72-75 (2009-08-19)
Marianna Mazza et al.
Expert opinion on pharmacotherapy, 8(5), 649-656 (2007-03-23)
Oxcarbazepine (OXC) is a keto-congener of carbamazepine, which has fewer side effects and drug interactions. However, the efficacy of OXC in treating bipolar disorder is not as well established as that of carbamazepine. This article is a systematic literature review
Penny Bring et al.
Clinical pharmacokinetics, 47(12), 767-778 (2008-11-26)
Oxcarbazepine, the 10-keto analogue of carbamazepine, is approved for the treatment of partial seizures or generalized tonic-clonic seizures. The primary metabolite of oxcarbazepine is monohydroxylated derivative (MHD). This review follows a decision-making algorithm to determine if therapeutic drug monitoring of
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