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Merck
CN

911690

C5 Lenalidomide

≥95%

别名:

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC® research

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关于此项目

经验公式（希尔记法）:
C13H13N3O3
化学文摘社编号:
191732-70-4
分子量:
259.26
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
MFCD31692701

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产品名称

C5 Lenalidomide, ≥95%

InChI

1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)

InChI key

WLUIQUZGNPAKRL-UHFFFAOYSA-N

SMILES string

NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1

ligand

C5 Lenalidomide

assay

≥95%

form

powder

reaction suitability

reagent type: ligand

storage temp.

2-8°C

Quality Level

100

相关类别

Application

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2

target_organs

Blood

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000375893
0000375893
MKCM1381

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