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Merck
CN

913979

Biotin-Thalidomide

≥95%

别名:

N1-(4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide, Biotin-conjugated thalidomide, bio-Thal

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关于此项目

经验公式（希尔记法）:
C44H64N8O13S
化学文摘社编号:
2230857-87-9
分子量:
945.09
MDL number:
MFCD32851674
UNSPSC Code:
12352200
NACRES:
NA.22

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产品名称

Biotin-Thalidomide, ≥95%

InChI

1S/C44H64N8O13S/c53-34(12-2-1-11-33-40-30(28-66-33)49-44(61)51-40)46-19-7-21-62-23-25-64-26-24-63-22-8-20-47-36(55)14-6-13-35(54)45-17-3-4-18-48-38(57)27-65-32-10-5-9-29-39(32)43(60)52(42(29)59)31-15-16-37(56)50-41(31)58/h5,9-10,30-31,33,40H,1-4,6-8,11-28

InChI key

UCTZYEDSVDZJQR-NTZPKYJMSA-N

SMILES string

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@](NC(N5)=O)([H])[C@]5([H])CS4)=O)=O)=O)=O)=O)NC1=O

ligand

thalidomide

assay

≥95%

form

powder

storage temp.

−20°C

Quality Level

100

相关类别

Application

Biotin-Thalidomide (bio-Thal) is a cereblon affinity probe for PROTAC® and targeted protein degradation research. Bio-Thal can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

The dTAG system for immediate and target-specific protein degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
MKCW6162
MKCW1268
MKCR4973
MKCM4001

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Behnam Nabet et al.
Nature chemical biology, 14(5), 431-441 (2018-03-28)
Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the requisite delay between modulation to experimental measurement. To enable the

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