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901487

(S,S,S)-AHPC hydrochloride

Name: (S,S,S)-AHPC hydrochloride
Brand: ALDRICH

≥97%

别名:

(2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand negative control epimer, Ligand for PROTAC^® research, VH032 negative control

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About This Item

经验公式（希尔记法）:

C₂₂H₃₀N₄O₃S · xHCl

CAS号:

2115897-23-7

分子量:

430.56 (free base basis)

MDL编号:

MFCD32062443

UNSPSC代码:

12352101

NACRES:

NA.22

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Sigma-Aldrich

901490

(S,R,S)-AHPC hydrochloride

Sigma-Aldrich

901511

(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

Sigma-Aldrich

920908

(S,R,S)-VL285 Phenol

Sigma-Aldrich

901488

(S,R,S)-AHPC-PEG₂-NH₂ hydrochloride

Sigma-Aldrich

SML2923

ARV-771

Sigma-Aldrich

924229

(S,R,S)-AHPC-Me

Sigma-Aldrich

904880

Pomalidomide-C₆-PEG₁-C₃-PEG₁-butyl azide

Sigma-Aldrich

904651

(S,R,S)-AHPC-PEG₃-azide

Sigma-Aldrich

903957

(S,R,S)-AHPC-PEG1-azide

Sigma-Aldrich

901493

(S,R,S)-AHPC-PEG₁-NH₂ hydrochloride

ligand

VH032

质量水平

100

方案

≥97%

表单

powder or crystals

反应适用性

reagent type: ligand

储存温度

2-8°C

SMILES字符串

N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@H](O)C1)=O)C(C)(C)C.Cl

InChI

1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17-,19+;/m0./s1

InChI key

JYRTWGCWUBURGU-ITJMAPPJSA-N

应用

(S,S,S)-AHPC (HCl salt) is a ligand used as a negative control for (S,R,S)-AHPC (cat# 901490) in the recruitment of the von Hippel–Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Small-Molecule PROTACS: New Approaches to Protein Degradation

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000399303

MKCR9864

MKCG6337

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.

Andrew P Crew et al.

Journal of medicinal chemistry, 61(2), 583-598 (2017-07-12)

Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent degradation of that protein. While the field of targeted degraders is still relatively young, the potential for this modality

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).

Pedro Soares et al.

Journal of medicinal chemistry, 61(2), 599-618 (2017-08-31)

The von Hippel-Lindau tumor suppressor protein is the substrate binding subunit of the VHL E3 ubiquitin ligase, which targets hydroxylated α subunit of hypoxia inducible factors (HIFs) for ubiquitination and subsequent proteasomal degradation. VHL is a potential target for treating

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Michael Zengerle et al.

ACS chemical biology, 10(8), 1770-1777 (2015-06-03)

The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1. However, the lack of intra-BET selectivity limits the scope of current

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

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Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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(S,S,S)-AHPC hydrochloride

≥97%

About This Item

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ligand

质量水平

方案

表单

反应适用性

储存温度

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InChI

InChI key

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储存分类代码

WGK

闪点(°F)

闪点(°C)

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