所有图片(2)

主要文件

COO原产地证书/COA分析证书

查看所有文档

901860

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride

Name: (S,R,S)-AHPC-PEG6-NH2 hydrochloride
Brand: ALDRICH

≥95%

别名:

(2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate

登录查看公司和协议定价

所有图片(2)

About This Item

经验公式（希尔记法）:

C₃₆H₅₈ClN₅O₁₀S

分子量:

788.39

MDL编号:

MFCD32173800

UNSPSC代码:

12352101

NACRES:

NA.22

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

901493

(S,R,S)-AHPC-PEG₁-NH₂ hydrochloride

Sigma-Aldrich

901488

(S,R,S)-AHPC-PEG₂-NH₂ hydrochloride

Sigma-Aldrich

901831

Pomalidomide-PEG₅-NH₂hydrochloride

Sigma-Aldrich

901511

(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

Sigma-Aldrich

901490

(S,R,S)-AHPC hydrochloride

Sigma-Aldrich

920908

(S,R,S)-VL285 Phenol

Sigma-Aldrich

920606

(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH₂ hydrochloride

Sigma-Aldrich

901830

Pomalidomide-PEG₄-NH₂ hydrochloride

Sigma-Aldrich

901848

(S,R,S)-AHPC-PEG₄-NH₂ hydrochloride

Sigma-Aldrich

901565

Propargyl-PEG₃-acid

ligand

VH032

方案

≥95%

表单

powder or crystals

反应适用性

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

官能团

amine

储存温度

2-8°C

SMILES字符串

O=C(COCCOCCOCCOCCOCCOCCN)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

InChI

1S/C36H57N5O10S.ClH/c1-26-32(52-25-39-26)28-7-5-27(6-8-28)22-38-34(44)30-21-29(42)23-41(30)35(45)33(36(2,3)4)40-31(43)24-51-20-19-50-18-17-49-16-15-48-14-13-47-12-11-46-10-9-37;/h5-8,25,29-30,33,42H,9-24,37H2,1-4H3,(H,38,44)(H,40,43);1H/t29-,30+,33-;/m1./

InChI key

KGOMUHLTEFUWTP-ZLLRWCRQSA-N

应用

Protein degrader building block (S,R,S)-AHPC-PEG₆-NH₂ (HCL salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

警示用语：

Warning

危险声明

H302,H315,H319

预防措施声明

P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Impact of linker length on the activity of PROTACs.

Kedra Cyrus et al.

Molecular bioSystems, 7(2), 359-364 (2010-10-06)

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

商品

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

主要文件

(S,R,S)-AHPC-PEG6-NH2 hydrochloride

≥95%

About This Item

推荐产品

属性

ligand

方案

表单

反应适用性

官能团

储存温度

SMILES字符串

InChI

InChI key

相关类别

说明

应用

其他说明

法律信息

相关产品

相关产品

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride