904848
2-Chloro-1,3-bis(2,6-diisopropylphenyl)imidazolium chloride
≥95%
别名:
1,3-Bis(2,6-di-i-propylphenyl)-2-chloroimidazolium chloride, Chloroimidazolium chloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C27H36Cl2N2
化学文摘社编号:
分子量:
459.49
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
SMILES string
[Cl+]=C1N(C=CN1c3c(cccc3C(C)C)C(C)C)c2c(cccc2C(C)C)C(C)C.[Cl-]
InChI
1S/C27H36ClN2.ClH/c1-17(2)21-11-9-12-22(18(3)4)25(21)29-15-16-30(27(29)28)26-23(19(5)6)13-10-14-24(26)20(7)8;/h9-20H,1-8H3;1H/q+1;/p-1
InChI key
JDMACANGISWEGX-UHFFFAOYSA-M
assay
≥95%
form
powder
functional group
chloro
Application
This chloroimidazolium chloride is used in the deoxyfluorination of phenols. Recently, the Ritter lab used it in conjunction with 902314 and 906794 to incorporate the [18F]fluoride radiolabel site specifically into polypeptides for use with positron emission tomography (PET) imaging in the study of various biological applications.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Martin G Strebl et al.
ACS central science, 3(9), 1006-1014 (2017-10-06)
Histone deacetylase 6 (HDAC6) function and dysregulation have been implicated in the etiology of certain cancers and more recently in central nervous system (CNS) disorders including Rett syndrome, Alzheimer's and Parkinson's diseases, and major depressive disorder. HDAC6-selective inhibitors have therapeutic
Nathaniel W Goldberg et al.
Organic letters, 18(23), 6102-6104 (2016-12-10)
A practical, high-yielding method for the deoxyfluorination of alcohols is presented using AlkylFluor, a novel salt analogue of PhenoFluor. AlkylFluor is readily prepared on multigram scale and is stable to long-term storage in air and exposure to water. The practicality
Teppei Fujimoto et al.
Organic letters, 17(3), 544-547 (2015-01-27)
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in
Corrigendum: Concerted nucleophilic aromatic substitution with 19F- and 18F.
Constanze N Neumann et al.
Nature, 538(7624), 274-274 (2016-08-04)
Jisu Back et al.
Journal of the American Chemical Society, 139(43), 15300-15303 (2017-10-19)
Notwithstanding the notable progress in the synthesis of N-heterocyclic carbene-stabilized radicals, aminyl radicals, supported by NHCs or otherwise, have been scarcely studied due to synthetic challenges. Triazenyl radical is a particular form of aminyl radical that contains three adjacent nitrogen
相关内容
The Ritter lab currently focuses on fluorination chemistry for late-stage functionalization of complex natural and unnatural products. PhenoFluor™ has been developed as a general reagent for the selective, predictable, direct deoxyfluorination of complex alcohols and phenols.
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