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反应适用性
reagent type: reductant
质量水平
浓度
1 M in THF
折射率
n20/D 1.423
密度
0.882 g/mL at 25 °C
储存温度
2-8°C
SMILES字符串
[Li+].[BH3-]N(C)C
InChI
1S/C2H9BN.Li/c1-4(2)3;/h1-3H3;/q-1;+1
InChI key
CEDUMRZWZLVFKS-UHFFFAOYSA-N
一般描述
Lithium dimethylaminoborohydride is a reagent exhibiting dual properties like a metal hydride and nitrogen nucleophile. It is generally considered as an alternative to lithium aluminum hydride (LAH) for the reduction of carbonyl compounds, amides, and lactams.
应用
在与卤代吡啶和伯烷基甲磺酸酯反应的情况下，LAB 可以转移胺部分。
能够还原各种官能团。
Lithium Aminoborohydride (LAB) Reagents
Reactant for:
Reactant for:
- B-H oxidative addition reactions
- Reduction and amination reactions
- Reduction of N-alkyl lactams
- Synthesis of tertiary amine-boranes
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官
Respiratory system
补充剂危害
储存分类代码
4.3 - Hazardous materials which set free flammable gases upon contact with water
WGK
WGK 3
闪点(°F)
1.4 °F - closed cup
闪点(°C)
-17 °C - closed cup
法规信息
危险化学品
Lithium aminoborohydrides: powerful, selective, air-stable reducing agents
Pasumansky L, et al.
Organic Process Research & Development, 10(5), 959-970 (2006)
Ab initio analysis of lithium dimethylaminoborohydride
Mogali S, et al.
The Journal of Organic Chemistry, 66(7), 2368-2373 (2001)
Shannon Thomas et al.
Organic letters, 5(21), 3867-3870 (2003-10-11)
[reaction: see text] Lithium aminoborohydride (LAB) reagents promote the amination of 2-fluoropyridine under mild reaction conditions, providing 2-(dialkylamino)pyridines in excellent yield and purity. Treatment of 2-fluoropyridine with 1.1 equiv of lithium aminoborohydride at room temperature affords complete conversion after 1
S Thomas et al.
Organic letters, 3(24), 3915-3918 (2001-11-27)
Lithium aminoborohydride (LAB) reagents initiate the amination or reduction of alkyl methanesulfonate esters, as dictated by reaction conditions. Alkyl methanesulfonate esters treated with unhindered LABs provide tertiary amines in excellent yield. Reduction to the corresponding alkane is achieved using a
Pasumansky, L. et al
Aldrichimica Acta, 38, 61-61 (2005)
商品
Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.
相关内容
New asymmetric methodology meets the continuous demand for optically active compounds in various fields.
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