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Merck
CN

462047

1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐

97%

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线性分子式:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
化学文摘社编号:
5370-01-4
分子量:
215.72
NACRES:
NA.22
PubChem Substance ID:
24869930
UNSPSC Code:
12352100
EC Number:
250-825-7
MDL number:
MFCD00216024
Assay:
97%
Form:
solid

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InChI key

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

InChI

1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

SMILES string

Cl.CC(N)COc1c(C)cccc1C

assay

97%

form

solid

mp

200-203 °C (lit.)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

General description

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
09708AR

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Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Angela K Clouse et al.
Urology, 79(6), 1410-1410 (2012-04-14)
To evaluate the consequence of pharmacologic inhibition of voltage-gated Na(+) channels (Nav) in the conscious rat, based on Nav having been implicated as modulators of rodent urodynamics using knockout as well as antisense oligodeoxynucleotide approaches. The urodynamic response to standard
Lushan Yu et al.
The Journal of pharmacy and pharmacology, 64(6), 792-801 (2012-05-11)
This study examined the interaction of mexiletine enantiomers with human plasma, human serum albumin (HSA), and human α1-acid glycoprotein (hAGP), and characterized the binding modes of mexiletine enantiomers with hAGP in the molecular level. Enantiomer separation of mexiletine was performed
Erythromelagia: a rare and hard-to-treat condition: a 9-year-old boy responsive to intravenous lidocaine and oral mexilitene.
Francisca Elgueta et al.
Pain medicine (Malden, Mass.), 14(2), 311-312 (2013-02-02)
Tomoyuki Suzuki et al.
Cardiovascular research, 98(1), 136-144 (2013-01-24)
Na(+) channel blockers are often used to treat atrial fibrillation (AF), but may sometimes cause ventricular contractile dysfunction. However, amiodarone, a multi-channel blocker with Na(+) channel block, causes less contractile dysfunction. In this study, we tested the hypothesis that Na(+)
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