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Merck
CN
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文件

安全信息

392731

Sigma-Aldrich

(DHQD)2PHAL

greener alternative

≥95%

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别名:
氢化奎尼定 1,4-(2,3-二氮杂萘)二醚
经验公式（希尔记法）:
C48H54N6O4
CAS号:
140853-10-7
分子量:
778.98
Beilstein:
5475678
MDL编号:
MFCD00198107
UNSPSC代码:
12352005
PubChem化学物质编号:
24864481
NACRES:
NA.22

检测方案

≥95%

形式

powder

旋光性

[α]22/D −262°, c = 1.2 in methanol

环保替代产品得分

old score: 5
new score: 3
Find out more about DOZN™ Scoring

环保替代产品特性

Waste Prevention
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

160 °C (dec.) (lit.)

环保替代产品分类

, Re-engineered

SMILES字符串

CC[C@H]1CN2CCC1CC2[C@@H](Oc3nnc(O[C@H](C4CC5CCN4C[C@@H]5CC)c6ccnc7ccc(OC)cc67)c8ccccc38)c9ccnc%10ccc(OC)cc9%10

InChI

1S/C48H54N6O4/c1-5-29-27-53-21-17-31(29)23-43(53)45(35-15-19-49-41-13-11-33(55-3)25-39(35)41)57-47-37-9-7-8-10-38(37)48(52-51-47)58-46(44-24-32-18-22-54(44)28-30(32)6-2)36-16-20-50-42-14-12-34(56-4)26-40(36)42/h7-16,19-20,25-26,29-32,43-46H,5-6,17-18,21-24,27-28H2,1-4H3/t29-,30-,31-,32-,43+,44+,45-,46-/m0/s1

InChI key

YUCBLVFHJWOYDN-HVLQGHBFSA-N

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相关类别

一般描述

(DHQD)2PHAL is a dimer that can be used as a chiral amine catalyst for asymmetric halogenations.

(DHQD)2PHAL is a modified cinchona alkaloid derivative mainly used as a ligand for enantioselective catalysis.
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, "Safer Solvents and Auxiliaries" and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

应用

(DHQD)2PHAL may be used as ligand for:
  • Osmium trioxide catalyzed asymmetric dihydroxylation of olefins.
  • Palladium catalyzed Suzuki-Miyaura coupling of aryl/heteroaryl halides with aryl boronic acids in aqueous medium and in the absence of phosphine/organic solvent.
  • Copper(I)-catalyzed azide-alkyne cycloaddition reaction to synthesize 1,2,3-triazoles in water.
Hydroquinidine 1,4-phthalazinediyl diether [(DHQD)2PHAL] can be used:
  • As a ligand for Sharpless asymmetric dihydroxylation.
  • For enantioselective α-fluorination of carbonyl compounds.

法律信息

经 Rhodia Pharma Solutions 授权销售。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Chemical Fixation of Carbon Dioxide Co-Catalyzed by a Combination of Schiff Bases or Phenols and Organic Bases.
Shen YM, et al.
European Journal of Organic Chemistry, 2004(14), 3080-3089 (2004)
Tetrahedron Asymmetry, 16, 3913-3913 (2005)
(DHQD) 2 PHAL ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition reactions in water at room temperature.
Ali AA, et al.
Royal Society of Chemistry Advances, 4(110), 64388-64392 (2014)
Pd (OAc) 2 and (DHQD) 2 PHAL as a simple, efficient and recyclable/reusable catalyst system for Suzuki-Miyaura cross-coupling reactions in H 2 O at room temperature.
Saikia B, et al.
New. J. Chem., 39(4), 2440-2443 (2015)
Syntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefins.
Amberg W, et al.
The Journal of Organic Chemistry, 58(4), 844-849 (1993)
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