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Merck
CN
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文件

202495

Sigma-Aldrich

聚乙二醇甲基醚

average MN 750, methoxy, hydroxyl

别名:

mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚

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About This Item

线性分子式:
CH3(OCH2CH2)nOH
CAS号:
9004-74-4
MDL编号:
MFCD00084416
UNSPSC代码:
12162002
PubChem化学物质编号:
24852093
NACRES:
NA.23

product name

聚乙二醇甲基醚, average Mn 750

蒸汽密度

>1 (vs air)

质量水平

200

蒸汽压

0.05 mmHg ( 20 °C)

形式

paste
solid

分子量

average Mn 750

折射率

n20/D 1.459

粘度

10.5 cSt(210 °F)(lit.)

转变温度

Tm 30 °C

密度

1.094 g/mL at 25 °C

Ω端

hydroxyl

α端

methoxy

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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应用

聚（乙二醇）甲基醚可用作：
  • 一种链转移剂，以通过金属开环寡聚反应合成两亲性嵌段共聚物。
  • 作为一种前体，用于制备视甲酸-聚乙二醇纳米组装体，以作为一种高效的药物给药系统
  • 制备与聚乳酸结合的双嵌段共聚物，并将其应用于组织工程和给药领域

WGK

WGK 1

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Eyeshields, Gloves

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Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
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