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H1512

Sigma-Aldrich

Haloperidol

≥98% (TLC), powder, dopamine receptor antagonist

Synonym(s):

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

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250 μG
¥4,489.38

¥4,489.38

Estimated to ship on2025年5月16日Details

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250 μG
¥4,489.38

About This Item

Empirical Formula (Hill Notation):
C21H23ClFNO2
CAS Number:
52-86-8
Molecular Weight:
375.86
EC Number:
200-155-6
MDL number:
MFCD00051423
UNSPSC Code:
12352200
PubChem Substance ID:
24277917
NACRES:
NA.77

¥4,489.38

Estimated to ship on2025年5月16日Details

Request a Bulk Order

Product Name

Haloperidol, powder

form

powder

Quality Level

200

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
0.1 M HCl: 3 mg/mL
DMSO: soluble
H2O: insoluble
ethanol: soluble

originator

Johnson & Johnson

SMILES string

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3

InChI

1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChI key

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243) , ADRA1A(148) , ADRA2A(150) , ADRA2C(152) , CHRM1(1128) , DRD2(1813) , DRD3(1814) , DRD4(1815) , EBP(10682) , HRH1(3269) , HTR2A(3356) , HTR2C(3358) , HTR7(3363) , KCNH1(3756) , KCNH2(3757) , PRNP(5621)
rat ... Adra1a(29412) , Adra2a(25083) , Chrm1(25229) , Chrm2(81645) , Drd1a(24316) , Drd2(24318) , Drd3(29238) , Drd4(25432) , Hrh1(24448) , Htr1a(24473) , Htr1b(25075) , Htr2a(29595) , Htr2c(25187) , Oprs1(29336) , Slc6a3(24898) , Slc6a4(25553)

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Show Differences

1 of 4

This Item
A9511A4327A8301
Albumin from human serum lyophilized powder, ≥96% (agarose gel electrophoresis)

A1653

Albumin from human serum

Albumin from human serum lyophilized powder, ≥97% (agarose gel electrophoresis)

A9511

Albumin from human serum

Albumin from human serum lyophilized powder, essentially protease free, ≥96% (agarose gel electrophoresis)

A4327

Albumin from human serum

Albumin, glycated human lyophilized powder

A8301

Albumin, glycated human

assay

≥96% (agarose gel electrophoresis)

assay

≥97% (agarose gel electrophoresis)

assay

≥96% (agarose gel electrophoresis)

assay

90-100% protein basis (biuret)

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

ELISA: suitable, western blot: suitable, tissue culture: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

technique(s)

tissue culture: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

HIV I and HIVII, HCV and HBsAg, tested negative

impurities

-

Application

Haloperidol has been used:
  • in ethanol to serves as an inhibitor of Erg2p[1]
  • to address the mechanism of haloperidol in ferroptosis using hepatocellular carcinoma cells: Hep G2 and Huh-7 cell lines[2]
  • in receptor internalization assay[3]
  • as an antipsychotic drug in Dulbecco′s Modified Eagle medium[4]

Biochem/physiol Actions

Haloperidol is a butyrophenone antipsychotic. It is also classified as a neuroleptic (powerful tranquilizer). Haloperidol acts as a D2, D3, and D4 dopamine receptor antagonist and thus causes Parkinson′s disorder. It also has a negative effect on the central nervous system.[5]

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF4894V
    WXBF2537V
    WXBF0898V
    WXBD9387V
    WXBD6346V

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    CRC Desk Reference of Clinical Pharmacology null
    Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells
    Jiang L, et al.
    BioMed Central Pharmacology, 9(1), 6-6 (2009)
    Yeast sphingolipids do not need to contain very long chain fatty acids
    Cerantola V, et al.
    The Biochemical Journal, 401(1), 205-216 (2007)
    Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells
    Bai T, et al.
    Biochemical and Biophysical Research Communications, 491(4), 919-925 (2017)
    Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling
    Jeong J, et al.
    Testing, 8(12), e84482-e84482 (2013)
    View All Related Papers

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