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Merck
CN
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文件

C6305

Sigma-Aldrich

氯氮平标准液

≥98% (TLC), powder, D₄-dopamine receptor antagonist

别名:

8-氯-11-（4-甲基-1-哌嗪基）-5H-二苯并[b,e][1,4]二氮杂卓

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About This Item

经验公式（希尔记法）:
C18H19ClN4
CAS号:
5786-21-0
分子量:
326.82
MDL编号:
MFCD00153785
UNSPSC代码:
12352200
PubChem化学物质编号:
24277892
NACRES:
NA.77

product name

氯氮平标准液,

形式

powder

质量水平

300

溶解性

ethanol: 1 mg/mL
0.1 M HCl: 30 mg/mL
DMSO: 4.8 mg/mL

创始人

Novartis

SMILES字符串

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

QZUDBNBUXVUHMW-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA2A(150) , ADRA2C(152) , CHRM1(1128) , DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HRH4(59340) , HTR2A(3356) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR6(3362) , HTR7(3363) , KCNH1(3756) , KCNH2(3757) , UGT1A4(54657)
rat ... Adra1a(29412) , Adra2a(25083) , Adrb1(24925) , Chrm1(25229) , Drd1a(24316) , Drd2(24318) , Drd3(29238) , Drd4(25432) , Hrh1(24448) , Htr1a(24473) , Htr1b(25075) , Htr2a(29595) , Htr2b(29581) , Htr2c(25187) , Htr3a(79246) , Htr7(65032) , Slc6a4(25553)

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生化/生理作用

非典型抗精神病化合物。D 4 -多巴胺受体的选择性拮抗剂。5-HT2A、5-HT2C、5-HT3、 5-HT6和 5-HT7 5-羟色胺受体拮抗剂。

特点和优势

《受体分类和信号转导》手册的 组胺受体 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由Novartis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

可比产品

产品编号
说明
价格

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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P B Bergqvist et al.
Psychopharmacology, 143(1), 89-96 (1999-05-05)
Low doses of the atypical antipsychotic drug risperidone are effective in patients with obsessive compulsive disorder (OCD) not responding to serotonin (5-HT) reuptake inhibitors, although higher doses have been reported to induce OCD symptoms in psychotic patients. Since such atypical
Valerio Zerbi et al.
Neuron, 103(4), 702-718 (2019-06-23)
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we
Owen Randlett et al.
Current biology : CB, 29(8), 1337-1345 (2019-04-09)
Habituation is a simple form of learning where animals learn to reduce their responses to repeated innocuous stimuli [1]. Habituation is thought to occur via at least two temporally and molecularly distinct mechanisms, which lead to short-term memories that last
Tarek K Rajji et al.
The American journal of psychiatry, 172(6), 579-585 (2015-04-11)
Clozapine's potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 receptor agonist activity. The authors hypothesized that
Alexandre Picard et al.
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The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In
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