跳转至内容
Merck
CN

D6821

Sigma-Aldrich

盐酸多奈哌齐

≥98% (HPLC), powder, acetylcholinesterase inhibitor

别名:

1 H -茚-1-酮,2,3-二氢-5,6-二甲氧基-2-\ [\ [1-(苯甲基)-4-哌啶基] 甲基]-, 盐酸盐, E2020

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C24H29NO3 · HCl
分子量:
415.95
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

product name

盐酸多奈哌齐, ≥98% (HPLC)

质量水平

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to off-white

溶解性

DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL

储存温度

room temp

SMILES字符串

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl

InChI

1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2

InChI key

HLJIZAKUNCTCQX-UHFFFAOYSA-N

基因信息

human ... ACHE(43)

正在寻找类似产品? 访问 产品对比指南

应用

用盐酸多奈哌齐进行量效实验,研究其改善尼古丁戒断所致小鼠环境条件反应缺陷的作用。还将其腹腔注射到大鼠体内,研究其改善社会行为缺陷、重复行为和多动的能力。

生化/生理作用

盐酸多奈哌齐一水合物是一种中枢作用的可逆性乙酰胆碱酯酶抑制剂。
盐酸多奈哌齐是一种含有有机化合物和非竞争性抑制剂的哌啶类药物。对治疗阿尔茨海默病(其中痴呆为突出症状)有效。已证实多奈哌齐可诱导认知能力和全身功能。其半衰期为 70 小时。

特点和优势

该化合物收录于受体分类和信号转导手册的乙酰胆碱合成和代谢页面。想要浏览手册的其他页面, 请单击此处

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral - Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Haneul Kim et al.
Journal of ethnopharmacology, 211, 38-46 (2017-09-18)
The seeds of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of Codonopsis lanceolata (Siedbold & Zucc.) Benth. & Hook. f ex Trautv. (Campanulaceae), contained in the DHP1402, have long been used for treating dementia
Donepezil for dementia due to Alzheimer's disease
Birks Jacqueline S and Harvey Richard J
Cochrane database of systematic reviews (Online), 6 (2018)
Gilbert Audira et al.
Biomolecules, 10(9) (2020-09-24)
Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects
Ji Hyun Kim et al.
Nutrients, 12(5) (2020-05-14)
Obesity increases risk of Alzheimer's Disease (AD). A high fat diet (HFD) can lead to amyloidosis and amyloid beta (Aβ) accumulation, which are hallmarks of AD. In this study, protective effects of the ethyl acetate fraction of Acer okamotoanum (EAO)
Sunhee Lee et al.
Phytotherapy research : PTR, 31(3), 425-432 (2017-02-07)
Acanthopanax koreanum Nakai (Araliaceae) is one of the most widely cultivated medicinal plants in Jeju Island, Korea, and the roots and stem bark of A. koreanum have been traditionally used as a tonic agent for general weakness. However, the use of

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门