D6821
盐酸多奈哌齐
≥98% (HPLC), powder, acetylcholinesterase inhibitor
别名:
1 H -茚-1-酮，2,3-二氢-5,6-二甲氧基-2-\ [\ [1-（苯甲基）-4-哌啶基] 甲基]-, 盐酸盐, E2020
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关于此项目
经验公式（希尔记法）:
C24H29NO3 · HCl
化学文摘社编号:
分子量:
415.95
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
盐酸多奈哌齐, ≥98% (HPLC)
SMILES string
O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
InChI key
HLJIZAKUNCTCQX-UHFFFAOYSA-N
InChI
1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL
storage temp.
room temp
Quality Level
Gene Information
human ... ACHE(43)
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Application
用盐酸多奈哌齐进行量效实验，研究其改善尼古丁戒断所致小鼠环境条件反应缺陷的作用。还将其腹腔注射到大鼠体内，研究其改善社会行为缺陷、重复行为和多动的能力。
Biochem/physiol Actions
一水合盐酸多奈哌齐是一种可逆性乙酰胆碱酯酶抑制剂
盐酸多奈哌齐一水合物是一种中枢作用的可逆性乙酰胆碱酯酶抑制剂。
盐酸多奈哌齐是一种含有有机化合物和非竞争性抑制剂的哌啶类药物。对治疗阿尔茨海默病（其中痴呆为突出症状）有效。已证实多奈哌齐可诱导认知能力和全身功能。其半衰期为 70 小时。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Eye Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gilbert Audira et al.
Biomolecules, 10(9) (2020-09-24)
Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects
The Effects of Donepezil in Alzheimer?s Disease--Results from a Multinational Trial1
Burns A, et al.
Dementia and Geriatric Cognitive Disorders, 10(3), 237-244 (1999)
Samantha L McLean et al.
Behavioural brain research, 302, 73-80 (2015-09-04)
Cholinergic dysfunction has been shown to be central to the pathophysiology of Alzheimer's disease and has also been postulated to contribute to cognitive dysfunction observed in various psychiatric disorders, including schizophrenia. Deficits are found across a number of cognitive domains
Ayijiang Habaike et al.
Cytotechnology, 72(4), 539-549 (2020-05-21)
Aggregation of Aβ is a pathological hallmark of Alzheimer's disease (AD). The purpose of this study was to identify the protective roles of different polysaccharide components in Fomes officinalis Ames polysaccharides (FOAPs) against Aβ25-35-induced neurotoxicity in PC12 cells. Different doses
Donepezil.
Bryson Harriet M and Benfield P
Drugs & Aging, 10(3), 234-239 (1997)
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