H4381
6-羟基多巴胺 盐酸盐
≥97% (titration), powder, neurotoxin
别名:
2,4,5-三羟基苯乙胺 盐酸盐, 2,5-二羟基酪胺 盐酸盐, 2-（2,4,5-三羟基苯基）乙胺 盐酸盐, 6-OHDA
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关于此项目
线性分子式:
(HO)3C6H2CH2CH2NH2 · HCl
化学文摘社编号:
分子量:
205.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
248-837-2
MDL number:
Beilstein/REAXYS Number:
4274007
产品名称
6-羟基多巴胺 盐酸盐, ≥97% (titration), powder
InChI key
QLMRJHFAGVFUAC-UHFFFAOYSA-N
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
SMILES string
Cl.NCCc1cc(O)c(O)cc1O
assay
≥97% (titration)
form
powder
color
off-white to brown
mp
232-233 °C (dec.) (lit.)
solubility
H2O: >50 mg/mL, clear, yellow to brown
storage temp.
room temp
Quality Level
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相关类别
Application
6-羟基多巴胺盐酸盐已被用于：
- 在大鼠中诱发帕金森症′（PD）
- 分析6-OHDA对PC12细胞的细胞毒性
- 诱导来自蓝斑中的去甲肾上腺素能（NA）神经元缺失
Biochem/physiol Actions
破坏儿茶酚胺能神经末端的神经毒素。
Disclaimer
吸湿
General description
6-羟基多巴胺盐酸盐（6-OHDA）是一种神经毒素，通常用于诱导帕金森症′（PD）。6-OHDA可导致黑质致密部的多巴胺能神经元死亡，从而渐进式模仿PD。6-OHDA是高度可氧化的，其不能穿过血脑屏障。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。在很多 体外 模型中，如原代神经元培养、人神经母细胞瘤细胞系、以及大鼠肾上腺嗜铬细胞瘤细胞系PC12，6-OHDA会导致许多神经元细胞的死亡。
Other Notes
Preparation Note
溶于含有0.1％偏亚硫酸氢钠或其他抗氧化剂的无氧水中。
溶液应新鲜制备，并避免暴露在光线下。溶液在氧化时会变红。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model
Hernandez-Baltazar D, et al.
Neurologia (Barcelona, Spain), 32(8), 533-539 (2017)
Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and-independent action
Saito Y, et al.
Free Radical Biology & Medicine, 42(5), 675-685 (2007)
Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease
Han F, et al.
Cytotherapy, 17(5), 665-679 (2015)
Hanming Ge et al.
Experimental and molecular pathology, 109, 16-24 (2019-05-09)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in
Víctor Fernández-Dueñas et al.
International journal of molecular sciences, 20(14) (2019-07-26)
Background: Several biophysical techniques have been successfully implemented to detect G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have made it possible to ascertain the presence of GPCR heteromers in animal models of disease, no success has been accomplished in
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