跳转至内容
Merck
CN
所有图片(2)

主要文件

查看所有文档

安全信息

C5776

Sigma-Aldrich

可卡因标准液 盐酸盐

别名:

苯甲酰甲基芽子碱 盐酸盐

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C17H21NO4 · HCl
CAS号:
53-21-4
分子量:
339.81
EC 号:
200-167-1
MDL编号:
MFCD00058119
UNSPSC代码:
12352200
PubChem化学物质编号:
329775099
NACRES:
NA.77

表单

powder

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)

应用

forensics and toxicology

SMILES字符串

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

InChI key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

正在寻找类似产品? 访问 产品对比指南

应用

Cocaine hydrochloride has been used:
  • in saline control to study the effects of cocaine self-administration in mouse brain
  • as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
  • to examine conditioning to intravenous cocaine hydrochloride

生化/生理作用

分别以大约 300nM、900nM 和 400nM 的 Kis 抑制多巴胺、去甲肾上腺素和 5-羟色胺转运蛋白。不同于苯异丙胺，它不会影响儿茶酚胺的释放。

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000392520
0000392519
0000394194
0000379695
0000316076

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Michel Engeln et al.
Biological psychiatry, 87(11), 992-1000 (2019-12-21)
We previously showed that the transcription factor Egr3 (early growth response 3) is oppositely regulated in nucleus accumbens (NAc) cell subtypes 24 hours following cocaine exposure and bidirectionally mediates cocaine-related behaviors in male rodents. Overexpressing Egr3 in D2 receptor-containing medium
Benoît Forget et al.
Progress in neurobiology, 197, 101898-101898 (2020-08-26)
Cocaine addiction is a chronic and relapsing disorder with an important genetic component. Human candidate gene association studies showed that the single nucleotide polymorphism (SNP) rs16969968 in the α5 subunit (α5SNP) of nicotinic acetylcholine receptors (nAChRs), previously associated with increased
Maria E Burkovetskaya et al.
ACS chemical neuroscience, 11(15), 2231-2242 (2020-07-02)
Cocaine addiction remains a major public concern throughout the world especially in developed countries. In the last three decades, significant achievements have led to a greater understanding of the signaling pathways involved in the development of cocaine addiction; however, there
Maria E Burkovetskaya et al.
Neuroscience letters, 728, 134951-134951 (2020-04-13)
The evidence showing the involvement of microglial activation in the development of drug addiction remain scarce as microglia have not been systematically investigated in self-administered mice, a gold standard rodent model for drug addiction. Here we established the stable cocaine
Lauren J Jones et al.
Frontiers in behavioral neuroscience, 9, 246-246 (2015-10-07)
The zebrafish is an ideal model organism for behavioral genetics and neuroscience. The high conservation of genes and neurotransmitter pathways between zebrafish and other vertebrates permits the translation of research between species. Zebrafish behavior can be studied at both larval
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门