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A8404

Sigma-Aldrich

Amitriptyline hydrochloride

≥98% (TLC), powder

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10 G
¥568.29
25 G
¥1,004.77
100 G
¥2,756.45
250 G
¥4,621.97

¥568.29

Available to ship on2025年4月25日Details

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10 G
¥568.29
25 G
¥1,004.77
100 G
¥2,756.45
250 G
¥4,621.97

About This Item

Empirical Formula (Hill Notation):
C20H23N · HCl
CAS Number:
549-18-8
Molecular Weight:
313.86
EC Number:
208-964-6
MDL number:
MFCD00012537
UNSPSC Code:
12352200
PubChem Substance ID:
24278073
NACRES:
NA.77

¥568.29

Available to ship on2025年4月25日Details

Request a Bulk Order

Quality Level

200

Assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: soluble
ethanol: soluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

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羰基氰化物 4-（三氟甲氧基）苯腙 ≥98% (TLC), powder

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羰基氰化物 4-（三氟甲氧基）苯腙

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

>98% (TLC)

assay

≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: soluble, ethanol: soluble

solubility

H2O: 100 mg/mL, ethanol: soluble

solubility

H2O: soluble, ethanol: soluble

solubility

95% ethanol: soluble

color

white to off-white

color

-

color

white

color

yellow

Application

Amitriptyline hydrochloride has been used:
  • as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice[1]
  • as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood[2]
  • as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse[3]

Biochem/physiol Actions

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia.[4] It possesses antihistaminic, anticholinergic, and antiserotonimic properties.[5] Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.[4]
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Features and Benefits

Shelf-life of the powder is at least three years.

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H301,H319,H361d,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCB7377
    BCCH3794
    BCBV1175
    BCBQ4634V
    BCBN3158V

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    Nadine Beckmann et al.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(4), 1460-1471 (2017-10-17)
    Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. We investigated arthritis severity by measuring joint swelling
    Neha Maurya et al.
    Journal of biomolecular structure & dynamics, 35(6), 1367-1380 (2016-05-05)
    Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin (Hb), using steady-state and time-resolved fluorescence spectroscopy, UV-visible spectroscopy, and circular dichroism spectroscopy, in combination with molecular docking and molecular dynamic (MD) simulation methods. The steady-state fluorescence reveals
    Iulia Zoicas et al.
    PloS one, 11(9), e0162498-e0162498 (2016-09-07)
    Major depressive disorder is often associated with deficits in social and cognitive functioning. Mice transgenic for acid sphingomyelinase (t-ASM) were previously shown to have a depressive-like phenotype, which could be normalized by antidepressant treatment. Here, we investigated whether t-ASM mice
    Flow injection potentiometric determination of amitriptyline hydrochloride
    El-Nashar R M, et al.
    Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 78(2), 107-113 (2004)
    L A Carvalho et al.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 20(6), 379-387 (2010-03-17)
    Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Recently, we showed that this impairment is indeed due to
    View All Related Papers

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