C2920
羰基氰化物 4-（三氟甲氧基）苯腙
≥98% (HPLC), powder, Mitophagy inducer
别名:
FCCP, 羰基氰对三氟甲氧基苯腙
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关于此项目
线性分子式:
CF3OC6H4NHN=C(CN)2
化学文摘社编号:
分子量:
254.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-730-8
MDL number:
Beilstein/REAXYS Number:
664446
产品名称
羰基氰化物 4-（三氟甲氧基）苯腙, ≥98% (HPLC), powder
InChI key
BMZRVOVNUMQTIN-UHFFFAOYSA-N
InChI
1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
SMILES string
FC(F)(F)Oc1ccc(N\N=C(/C#N)C#N)cc1
assay
≥98% (HPLC)
form
powder
color
yellow
mp
174-175 °C (dec.) (lit.)
solubility
95% ethanol: soluble
storage temp.
2-8°C
Quality Level
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Application
碳酰腈4-三氟甲氧基苯腙(FCCP)可作为细胞培养的解偶联剂：用于研究其对产热脂肪细胞的影响，用于研究其对小鼠线粒体β-氧化的作用，用于研究其对小鼠骨髓来源树突状细胞的代谢影响。
General description
FCCP是一种质子载体（H+ 离子载体），也是线粒体氧化磷酸化的解偶联剂。它能够促使质膜和线粒体膜去极化。FCCP可影响细胞钙离子参与的各种活动。它还能抑制K+ 背景电流和诱导小量内向电流，降低0.1单位的pH，以及诱导胞内[Na+]升高。FCCP能刺激Mg2+-ATP酶活性，抑制β-淀粉样蛋白生成，以及模拟选择性谷氨酸激动剂N-甲基-D-天冬氨酸(NMDA)对线粒体超氧化物产生的影响。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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