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About This Item
经验公式（希尔记法）:
C20H23N · HCl
CAS号:
分子量:
313.86
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
amitriptyline
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key
KFYRPLNVJVHZGT-UHFFFAOYSA-N
基因信息
human ... SLC6A2(6530) , SLC6A4(6532)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Amitriptyline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
相关产品
产品编号
说明
价格
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Ghahramani P, et al.
Journal of Chromatography. B, Biomedical Applications, 685(2), 307-313 (1996)
Interaction of amphiphilic drug amitriptyline hydrochloride with β-cyclodextrin as studied by conductometry, surface tensiometry and viscometry.
Ali M S, et al.
Journal of Molecular Liquids, 167, 115-118 (2012)
Katja Kovacic et al.
The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)
To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively
Jennifer S Gewandter et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(7), 1807-1814 (2014-02-18)
Chemotherapy-induced peripheral neuropathy (CIPN) occurs in as high as 70% of patients receiving certain types of chemotherapy agents. The FDA has yet to approve a therapy for CIPN. The aim of this multicenter, phase III, randomized, double-blind, placebo-controlled trial was
Grzegorz Jagla et al.
Pharmacological reports : PR, 66(3), 459-465 (2014-06-07)
The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been proposed, but there
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