N7261
去甲替林 盐酸盐
≥98% (HPLC), norepinephrine and serotonin inhibitor, powder
别名:
3-（10,11-二氢-5 H -二苯并[ a , d ] 环庚烯-5-亚基）- N -甲基-1-丙胺 盐酸盐, 去甲阿米替林 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H21N · HCl
化学文摘社编号:
分子量:
299.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
212-973-0
MDL number:
产品名称
去甲替林 盐酸盐, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
ethanol: 100 mg/mL, H2O: soluble
originator
Eli Lilly
SMILES string
Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChI key
SHAYBENGXDALFF-UHFFFAOYSA-N
Gene Information
human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)
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Biochem/physiol Actions
与 5-羟色胺转运体 (K i = 161 nM) 相比，三环类抗抑郁药是去甲肾上腺素转运体 (K i = 3.4 nM) 的一种更强效的抑制剂。5-HT 2 5-羟色胺受体拮抗剂。
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Aravind Penmatsa et al.
Nature, 503(7474), 85-90 (2013-09-17)
Antidepressants targeting Na(+)/Cl(-)-coupled neurotransmitter uptake define a key therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying the molecular interactions that underlie the pharmacological activity of these transport inhibitors, and thus the mechanism by which the inhibitors lead
Robert A Power et al.
Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)
Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a
Matthew T Olson et al.
Clinical chemistry, 59(6), 920-927 (2013-02-22)
The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations. We measured
Lindsay F Stead et al.
The Cochrane database of systematic reviews, 12, CD009670-CD009670 (2012-12-14)
Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. To evaluate the effect of increasing the intensity of
SSRIs: a premature burial.
K Jensen
Clinical pharmacology and therapeutics, 93(3), 234-235 (2012-12-20)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N7261-10G | 04061834117940 |
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