N7261
去甲替林 盐酸盐
≥98% (HPLC), norepinephrine and serotonin inhibitor, powder
别名:
3-（10,11-二氢-5 H -二苯并[ a , d ] 环庚烯-5-亚基）- N -甲基-1-丙胺 盐酸盐, 去甲阿米替林 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H21N · HCl
化学文摘社编号:
分子量:
299.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
212-973-0
MDL number:
产品名称
去甲替林 盐酸盐, ≥98% (HPLC), powder
InChI key
SHAYBENGXDALFF-UHFFFAOYSA-N
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
SMILES string
Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
ethanol: 100 mg/mL
H2O: soluble
originator
Eli Lilly
Quality Level
Gene Information
human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)
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Biochem/physiol Actions
与 5-羟色胺转运体 (K i = 161 nM) 相比，三环类抗抑郁药是去甲肾上腺素转运体 (K i = 3.4 nM) 的一种更强效的抑制剂。5-HT 2 5-羟色胺受体拮抗剂。
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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The adsorption behaviors of a neutral (caffeine) and a positively charged compound (nortriptylinium) are investigated on two RPLC/hybrid stationary phases, eluted with a low ionic strength buffer (phosphate buffer, W(S)pH 2.63, I=10mM). The first phase, bridge ethylene hybrid (BEH), is
Matthew T Olson et al.
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The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations. We measured
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K Jensen
Clinical pharmacology and therapeutics, 93(3), 234-235 (2012-12-20)
Robert A Power et al.
Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)
Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a
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