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PHR1384

Supelco

盐酸阿米替林

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

盐酸阿米替林 盐酸盐, 10,11-二氢-N,N-二甲基-5H-二苯并[a,d]环庚烷-Δ5γ-丙胺盐酸盐, 3-（10,11-二氢-5H-二苯并[a,d]环庚烯-5-亚基）-N,N-二甲基-1-丙胺

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About This Item

经验公式（希尔记法）:
C20H23N · HCl
CAS号:
549-18-8
分子量:
313.86
EC 号:
208-964-6
MDL编号:
MFCD00012537
UNSPSC代码:
41116107
PubChem化学物质编号:
329823361
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 16
traceable to Ph. Eur. Y0000563
traceable to USP 1029002

API类

amitriptyline

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

基因信息

human ... SLC6A2(6530) , SLC6A4(6532)

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相关类别

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。盐酸阿米替林是一种药物，是一种具有抗胆碱能活性的三环类抗抑郁药。它广泛与氯氮卓7-氯-2-（甲基氨基）-5-苯基-3H-1，4-苯二氮卓-4-氧化物联合用于治疗伴有中度至重度焦虑的中度至重度抑郁症患者。

应用

盐酸阿米替林可作为药物标准品，通过分光光度技术和反相高效液相色谱技术对药物制剂中的分析物进行定量。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

三环类抗抑郁药；去甲肾上腺素和5-羟色胺转运体抑制剂；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。

分析说明

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

其他说明

该认证标准物质（CRM）根据ISO 17034和ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

附注

想要查看本品的检验报告示例，请在下框中输入LRAA1640。这只是一个示例证书，可能与您收到的批次不符。

相关产品

产品编号
说明
价格

1029002

盐酸阿米替林 盐酸盐, United States Pharmacopeia (USP) Reference Standard

D1000000

二苯并环庚酮, European Pharmacopoeia (EP) Reference Standard

Y0000563

盐酸阿米替林 盐酸盐, European Pharmacopoeia (EP) Reference Standard

1029013

二苯并软木酮, United States Pharmacopeia (USP) Reference Standard

1029024

Amitriptyline Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1776

阿米替林相关化合物B, Pharmaceutical Secondary Standard; Certified Reference Material

BP016

盐酸阿米替林 盐酸盐, British Pharmacopoeia (BP) Reference Standard

BP858

二苯并环庚酮, British Pharmacopoeia (BP) Reference Standard

PHR2836

Amitriptyline Related Compound A, certified reference material, pharmaceutical secondary standard

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Spectrophotometric and chromatographic simultaneous estimation of amitriptyline hydrochloride and chlordiazepoxide in tablet dosage forms
Patel S, et al.
Indian Journal of Pharmaceutical Sciences, 71(4), 472-472 (2009)
Simultaneous spectrophotometric determination of amitriptyline hydrochloride and chlordiazepoxide in pharmaceutical tablets by multivariate calibration method
Sarrafi MHA, et al.
Journal of Chemistry, 6(S1), S111-S116 (2009)
Katja Kovacic et al.
The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)
To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively
Mariola Herbet et al.
Acta poloniae pharmaceutica, 70(5), 913-917 (2013-10-24)
The aim of the present study was to assess the impact of combined therapy with rosuvastatin (10 mg/kg) and amitriptyline (10 mg/kg) on oxidation-reduction status in the blood of rats. After 2-week application of drugs alone or their combination, the
Jennifer S Gewandter et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(7), 1807-1814 (2014-02-18)
Chemotherapy-induced peripheral neuropathy (CIPN) occurs in as high as 70% of patients receiving certain types of chemotherapy agents. The FDA has yet to approve a therapy for CIPN. The aim of this multicenter, phase III, randomized, double-blind, placebo-controlled trial was
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