TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
别名:
APO2L, Apo-2L, CD253, TL2, TRAIL
物种:
Human TNFSF10 (8743), Mouse Tnfsf10 (22035), Rat Tnfsf10 (246775), naked mole-rat Tnfsf10 (101702439), domestic guinea pig Tnfsf10 (100734497), cow TNFSF10 (507215), sheep TNFSF10 (101114153), domestic cat TNFSF10 (101083289), domestic cat TNFSF10 (100174789), dog TNFSF10 (100174780) ...展开
UniProtKB ID:
基因ID:
- Human(8743) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(22035) tumor necrosis factor (ligand) superfamily, member 10
- Rat(246775) tumor necrosis factor (ligand) superfamily, member 10
- naked mole-rat(101702439) tumor necrosis factor (ligand) superfamily, member 10
- domestic guinea pig(100734497) tumor necrosis factor (ligand) superfamily, member 10
- cow(507215) tumor necrosis factor (ligand) superfamily, member 10
- sheep(101114153) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(101083289) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(100174789) tumor necrosis factor (ligand) superfamily, member 10
- dog(100174780) tumor necrosis factor (ligand) superfamily, member 10
- Zebrafish(436866) tumor necrosis factor (ligand) superfamily, member 10
- chicken(378894) tumor necrosis factor (ligand) superfamily, member 10
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ELISA
Antibodies
货号
说明
物种反应性
应用
Anti-TNFSF10 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-TNFSF10 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
western blot
Anti-TRAIL/CD253 Antibody, clone 6D12.2, clone 6D12.2, from mouse,
物种反应性
human
应用
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-Trail antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
货号
说明
物种
TRAIL蛋白，重组人类, Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.,
物种
human
TRAIL, Soluble human, recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE),
物种
human
TRAIL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder,
物种
human
TRAIL, Soluble mouse, recombinant, expressed in E. coli, His tagged, >95% (SDS-PAGE),
物种
mouse