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主要文件

安全信息

SRP3237

Sigma-Aldrich

TRAIL from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

别名:

Apo2 Ligand, TL2, TNF-related apoptosis-inducing Ligand, TNFSF10

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.32

¥4,637.12

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生物来源

mouse

重组

expressed in E. coli

方案

≥95% (HPLC)
≥95% (SDS-PAGE)

表单

lyophilized

效能

40.0-60.0 ng/mL ED50

分子量

20.0 kDa

包装

pkg of 50 μg

技术

cell culture | mammalian: suitable

杂质

<0.1 EU/μg endotoxin, tested

颜色

white

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Anti-Rabbit IgG (whole molecule)&#8722;FITC antibody produced in sheep affinity isolated antibody, buffered aqueous solution

F7512

Anti-Rabbit IgG (whole molecule)−FITC antibody produced in sheep

technique(s)

immunofluorescence: 1:64-1:128 using Hep2 cells

technique(s)

ANA-indirect immunofluorescence: 1:128, direct immunofluorescence: 1:80

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100, indirect immunofluorescence: 1:100

technique(s)

direct immunofluorescence: 1:160, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:160

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

sheep

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

一般描述

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a cytotoxic protein. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.

生化/生理作用

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, death receptor 4 and 5 (DR4 and 5). These receptors belong to the tumor necrosis factor receptor (TNFR) superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell′s apoptotic machinery.[1]

序列

MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0312450
    0210450

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    Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
    Chaudhary PM
    Immunity, 7(6), 821-830 (1997)
    S A Marsters et al.
    Recent progress in hormone research, 54, 225-234 (1999-11-05)
    Apo2 ligand (Apo2L, also called TRAIL) is a member of the tumor necrosis factor (TNF) cytokine family. The closest homolog of Apo2L is CD95 (Fas/Apo1) ligand, to which it has 24% amino acid sequence identity. Similar to CD95L, Apo2L activates
    G Pan et al.
    Science (New York, N.Y.), 277(5327), 815-818 (1997-08-08)
    TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as
    Abdul G Hameed et al.
    The Journal of experimental medicine, 209(11), 1919-1935 (2012-10-17)
    Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive narrowing and occlusion of small pulmonary arteries. Current therapies fail to fully reverse this vascular remodeling. Identifying key pathways in disease pathogenesis is therefore required for the development
    Apoptosis by death factor.
    S Nagata
    Cell, 88(3), 355-365 (1997-02-07)
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