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此商品 | T5694 | SRP3237 | SRP6238 |
|---|---|---|---|
| biological source human | biological source human | biological source mouse | biological source rat |
| recombinant expressed in E. coli | recombinant expressed in NSO cells | recombinant expressed in E. coli | recombinant expressed in E. coli |
| technique(s) immunofluorescence: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - |
| form lyophilized powder | form lyophilized powder | form lyophilized | form lyophilized powder |
| mol wt 19.6 kDa, predicted mol wt ~21 kDa | mol wt 24 kDa by SDS-PAGE, predicted mol wt ~21 kDa | mol wt 20.0 kDa | mol wt 20 kDa |
应用
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments.[1] The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).[2]
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.[3]
生化/生理作用
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells.[4] Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
TRAIL is a cytokine with anti-inflammatory,[5] and antitumor activity.[6] It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.[5]
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
外形
Lyophilized from phosphate buffered saline
分析说明
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Fatih Birtekocak et al.
Iranian journal of pharmaceutical research : IJPR, 20(2), 45-56 (2021-09-28)
Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a potential anti-cancer activity that is widely used
Lower maternal serum tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in early preeclampsia. A retrospective study
Morano D, et al.
Pregnancy hypertension, 12, 1-5 (2018)
Melanoma antigen-D2: a nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot C, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 581-595 (2016)
Jan E Carette et al.
Nature biotechnology, 29(6), 542-546 (2011-05-31)
Insertional mutagenesis in a haploid background can disrupt gene function. We extend our earlier work by using a retroviral gene-trap vector to generate insertions in >98% of the genes expressed in a human cancer cell line that is haploid for
Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells
Liu J, et al.
Clinical and Experimental Medicine, 1-13 (2018)
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