ATM
ataxia telangiectasia mutated
别名:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
物种:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Thale Cress ATM (823975), Zebrafish atm (403064), chicken ATM (395401), dog ATM (479450), domestic cat ATM (101089291), Horse ATM (100061765), cow ATM (526824) ...展开
UniProtKB ID:
基因ID:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- Zebrafish(403064) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- naked mole-rat(101718948) ataxia telangiectasia mutated
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
抗磷酸ATM（Ser1981）抗体，克隆10H11.E12, clone 10H11.E12, Upstate®, from mouse,
物种反应性
human, mouse
应用
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
抗-ATM 磷酸化Ser1981抗体（克隆10H11.E12）, clone 10H11.E12, Chemicon®, from mouse,
物种反应性
human, mouse
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-p-ATM (Ser1981) Antibody, clone 1E19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Proteins
货号
说明
物种