Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

We are planning system maintenance between Friday, Apr 11 at 9:00 PM CDT and Saturday, Apr 12 at 9:00 AM CDT. This will impact both web and offline transactions, including online orders, quotes, price and availability checks, and order status inquiries. We apologize for any inconvenience.

Merck
CN

ALPL

alkaline phosphatase, liver/bone/kidney

Synonyms:
AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
Species:
Human ALPL (249), Mouse Alpl (11647), Rat Alpl (25586), naked mole-rat Alpl (101725910), Zebrafish alpl (393982), chicken ALPL (396317), sheep ALPL (101123195), cow ALPL (280994), domestic cat ALPL (727689), domestic guinea pig Alpl (100718683)
UniProtKB ID:
P05186, A1A4E7, B2RMP8, B7Z387, B7Z4Y6, O75090, Q2TAI7, Q59EJ7
Gene ID:
  • Human(249) Summary: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
  • Mouse(11647) alkaline phosphatase, liver/bone/kidney
  • Rat(25586) alkaline phosphatase, liver/bone/kidney
  • naked mole-rat(101725910) alkaline phosphatase, liver/bone/kidney
  • Zebrafish(393982) alkaline phosphatase, liver/bone/kidney
  • chicken(396317) alkaline phosphatase, liver/bone/kidney
  • sheep(101123195) alkaline phosphatase, liver/bone/kidney
  • cow(280994) alkaline phosphatase, liver/bone/kidney
  • domestic cat(727689) alkaline phosphatase, liver/bone/kidney
  • domestic guinea pig(100718683) alkaline phosphatase, liver/bone/kidney
  • dog(403548) alkaline phosphatase, liver/bone/kidney

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
RAB1022
Human ALKP ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
HPA007105
Anti-ALPL antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
HPA008765
Anti-ALPL antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB1410456
Anti-ALPL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
A9469
Monoclonal ANTI-FLAG® M2-Alkaline Phosphatase antibody produced in mouse, clone M2, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
all
Application
ELISA
SAB5300345
Monoclonal Anti-ALPL antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
381551
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one, 97%,
Species
rat

Kits

Product Number
Description
Species
APF
Alkaline Phosphatase Detection Kit, Fluorescence, ,
Species
human

esiRNA

Product Number
Description
Species
EMU049921
MISSION® esiRNA, targeting mouse Alpl,
Species
mouse
EHU047461
MISSION® esiRNA, targeting human ALPL,
Species
human