381551
7-异丙氧基-3-苯基-4H-1-苯并吡喃-4-酮
97%
别名:
（依普黄酮）
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H16O3
化学文摘社编号:
分子量:
280.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
InChI
1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
SMILES string
CC(C)Oc1ccc2c(OC=C(C2=O)c3ccccc3)c1
InChI key
SFBODOKJTYAUCM-UHFFFAOYSA-N
assay
97%
mp
116-120 °C (lit.)
functional group
ketone, phenyl
Quality Level
Gene Information
rat ... Alpl(25586)
General description
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone), a synthetic flavonoid, is reported to stimulate the activity of osteoblasts. It is reported to promote the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like (ROB) cells as well as the activity of alkaline phosphatase. Ipriflavone, an isoflavone derivative, is a new drug used to decrease bone loss in osteoporosis.
Application
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone) has been used as a model drug in a study to functionalize the mesoporous bioactive glasses (MBG). Study suggested that since ipriflavone is a hydrophobic anti-osteoporotic drug, it easily attaches to the surface of MBG and results in long-term drug delivery.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Pedro Martins Bellei et al.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 34(1), 22-27 (2012-02-24)
Evaluate the effects of ipriflavone during fetogenesis, since no studies have been conducted to assess its effect during this period. 60 pregnant rats were divided randomly into four groups (n=15). G-control (1 mL of distilled water) and three groups treated
Adolfo López-Noriega et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 16(35), 10879-10886 (2010-07-28)
Mesoporous bioactive glasses (MBGs) associated with an anti-osteoporotic drug (ipriflavone) have been prepared. With this aim, MBGs were functionalised with different organic groups by following a post-grafting method, thus retaining the mesoporous network of the bioactive substrates. Drug-delivery tests were
[Effect of ipriflavone on growth and blood testosterone level in male rats].
Hui-jun Guo et al.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 25(2), 170-171 (2009-05-01)
Shirin Hooshmand et al.
Clinical nutrition (Edinburgh, Scotland), 27(4), 643-648 (2008-06-24)
Recent reports have indicated that soy isoflavones may be protective against breast cancer. However, the effects of the synthetic isoflavone, ipriflavone, on mammary tumorigenisis, alone or in combination with genistin, a soy isoflavone, have not been investigated. Eighty-eight 36-day-old female
H Hagiwara et al.
Journal of biochemistry, 126(1), 168-173 (1999-07-07)
Ipriflavone (7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one) is a synthetic flavonoid that has been shown to stimulate the activity of osteoblasts. We show here that ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like (ROB) cells
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持