跳转至内容

很抱歉,目前系统维护中。在此期间,网站下单功能无法使用。给您带来不便,深表歉意。如需其他帮助,请联系客户联络中心:400 620 3333。

Merck
CN
  • Cell death from antibiotics without the involvement of reactive oxygen species.

Cell death from antibiotics without the involvement of reactive oxygen species.

Science (New York, N.Y.) (2013-03-09)
Yuanyuan Liu, James A Imlay
摘要

Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to improve antibiotic efficacy. In this study, the model was directly tested. Contrary to the hypothesis, antibiotic treatment did not accelerate the formation of hydrogen peroxide in Escherichia coli and did not elevate intracellular free iron, an essential reactant for the production of lethal damage. Lethality persisted in the absence of oxygen, and DNA repair mutants were not hypersensitive, undermining the idea that toxicity arose from oxidative DNA lesions. We conclude that these antibiotic exposures did not produce ROS and that lethality more likely resulted from the direct inhibition of cell-wall assembly, protein synthesis, and DNA replication.

材料
货号
品牌
产品描述

Sigma-Aldrich
氨苄西林 钠盐
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 g
预计发货时间 2025年4月07日
详情...
¥1,277.53
Sigma-Aldrich
氨苄西林 三水合物, 900-1050 μg/mg anhydrous basis (HPLC)
登录查看公司和协议定价
货号包装规格是否有货价格数量
5 g
预计发货时间 2025年6月26日
详情...
¥400.27
Supelco
诺氟沙星, analytical standard, ≥98% (TLC)
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 g
预计发货时间 2025年4月07日
详情...
¥228.58
5 g
预计发货时间 2025年4月07日
详情...
¥772.61
Supelco
诺氟沙星, VETRANAL®, analytical standard
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 mg
预计发货时间 2025年4月07日
详情...
¥1,917.69