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33899

Supelco

诺氟沙星

VETRANAL®, analytical standard

别名:

1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸, 1-乙基-6-氟-1,4-二氢-4-氧代-7-哌嗪-3-喹啉羧酸

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15 G
¥6,072.73

¥6,072.73

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15 G
¥6,072.73

About This Item

经验公式（希尔记法）:
C16H18FN3O3
CAS号:
70458-96-7
分子量:
319.33
EC 号:
274-614-4
MDL编号:
MFCD00079532
UNSPSC代码:
41116107
PubChem化学物质编号:
329754535
NACRES:
NA.24

¥6,072.73

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等级

analytical standard

质量水平

100

Agency

EPA 1694

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

clinical testing

包装形式

neat

储存温度

2-8°C

SMILES字符串

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

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此商品
118151188711809
Coated GC Packing phase SP®-1000, 0.1%, matrix 80/100 Carbopack C support, bottle of 15 g

11820

Coated GC Packing

Supelco

11815

Coated GC Packing

Coated GC Packing phase 4% Carbowax 20M + 0.8% KOH, matrix 60/80 Carbopack B support, bottle of 15 g

11887

Coated GC Packing

Coated GC Packing phase 1% SP®-1510, matrix 60/80 Carbopack B support, bottle of 15 g

11809

Coated GC Packing

matrix active group

SP®-1000 phase, 0.1%

matrix active group

SP®-1000 phase, 1%

matrix active group

4% Carbowax 20M + 0.8% KOH phase

matrix active group

1% SP®-1510 phase

parameter

60-225 °C temp. range

parameter

60-225 °C temp. range

parameter

60-220 °C temp. range

parameter

60-230 °C temp. range

compatibility

for analyte group phenols

compatibility

for analyte group halogenated organics

compatibility

for analyte group amines

compatibility

for analyte group Industrial solvents

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

column type

packed GC

column type

packed GC

column type

packed GC

column type

packed GC

packaging

bottle of 15 g

packaging

bottle of 15 g

packaging

bottle of 15 g

packaging

bottle of 15 g

一般描述

诺氟沙星是一种抗菌药物，属于氟喹诺酮类（FQ），对多种革兰氏阴性和革兰氏阳性菌具有广谱抗菌活性。[1]

应用

有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。
诺氟沙星可作为分析参考标准品，通过各种色谱技术对药物制剂、[1]生物体液[1]和污水[2]中的分析物进行测定。

生化/生理作用

诺氟沙星通过干扰 ATP 诱导转换 DNA 与 DNA 旋转酶（拓扑异构酶）复合物的结构转换而阻断 DNA 复制。
操作方式：抑制细菌 DNA 复制
抗菌谱：革兰氏阴性菌； 对革兰氏阳性菌效果较差

法律信息

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCK4570
    BCCH7983
    BCBW5135

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    Determination of ofloxacin, norfloxacin, and ciprofloxacin in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry.
    Lee B-H, et al.
    Journal of Chromatography A, 1139(1), 45-52 (2007)
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    European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
    In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
    Lauren Becnel Boyd et al.
    Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)
    Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)
    Anita Reinhardt et al.
    Antimicrobial agents and chemotherapy, 51(4), 1341-1350 (2007-01-31)
    Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of
    Kenji Kurokawa et al.
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    The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the
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