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N9890

Supelco

诺氟沙星

analytical standard, ≥98% (TLC)

别名:

1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸, 1-乙基-6-氟-1,4-二氢-4-氧代-7-哌嗪-3-喹啉羧酸

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1 EA
¥3,330.29

¥3,330.29

预计发货时间2025年7月23日详情

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1 EA
¥3,330.29

About This Item

经验公式（希尔记法）:
C16H18FN3O3
CAS号:
70458-96-7
分子量:
319.33
EC 号:
274-614-4
MDL编号:
MFCD00079532
UNSPSC代码:
41116107
PubChem化学物质编号:
329818696
NACRES:
NA.24

¥3,330.29

预计发货时间2025年7月23日详情

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等级

analytical standard

质量水平

200

Agency

EPA 1694

方案

≥98% (TLC)

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

clinical testing

包装形式

neat

储存温度

2-8°C

SMILES字符串

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

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Tungsten wire reel, 5m, diameter 0.005mm, gold plated, 99.95%

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Tungsten wire reel, 5m, diameter 0.015mm, gold plated, 99.95%

GF58091991

Tungsten

Tungsten wire reel, 5m, diameter 0.025mm, gold plated, 99.95%

GF84044189

Tungsten

Tungsten wire reel, 5m, diameter 0.030mm, gold plated, 99.95%

GF56554926

Tungsten

assay

99.95%

assay

99.95%

assay

99.95%

assay

99.95%

form

wire

form

wire

form

wire

form

wire

manufacturer/tradename

Goodfellow 395-018-17

manufacturer/tradename

Goodfellow 580-919-91

manufacturer/tradename

Goodfellow 840-441-89

manufacturer/tradename

Goodfellow 565-549-26

mp

3410 °C (lit.)

mp

3410 °C (lit.)

mp

3410 °C (lit.)

mp

3410 °C (lit.)

bp

5660 °C (lit.)

bp

5660 °C (lit.)

bp

5660 °C (lit.)

bp

5660 °C (lit.)

density

19.3 g/mL at 25 °C (lit.)

density

19.3 g/mL at 25 °C (lit.)

density

19.3 g/mL at 25 °C (lit.)

density

19.3 g/mL at 25 °C (lit.)

一般描述

化学结构式：氟喹诺酮类
诺氟沙星 (Norfloxacin) 是一种广谱抗菌药物，对多种革兰氏阳性菌和阴性菌均有抗菌活性。[1]

应用

参考产品的检验报告，了解更多关于合适仪器技术的信息。联系技术服务部寻求进一步支持。
诺氟沙星可作为标准品使用荧光分光光度法测定人血清样品中的诺氟沙星。[1]

生化/生理作用

诺氟沙星通过干扰 ATP 诱导转换 DNA 与 DNA 旋转酶（拓扑异构酶）复合物的结构转换而阻断 DNA 复制。
操作方式：抑制细菌 DNA 复制
抗菌谱：革兰氏阴性菌； 对革兰氏阳性菌效果较差

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000227061
    0000249280
    0000249279
    0000227061
    0000249280

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    Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium
    Djurdjevic.TP, et al.
    Analytica Chimica Acta, 300, 253-259 (1995)
    L M Cavaco et al.
    Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)
    Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not
    Deepika Sharma et al.
    European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
    In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
    Anita Reinhardt et al.
    Antimicrobial agents and chemotherapy, 51(4), 1341-1350 (2007-01-31)
    Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of
    Lauren Becnel Boyd et al.
    Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)
    Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)
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    喹诺酮类药物是一类重要的抗生素，它们通过抑制拓扑异构酶来干扰DNA合成，最常见的是拓扑异构酶II（DNA旋转酶），它是一种参与DNA复制的酶。

    Inhibition of Nucleic Acid Synthesis by Antibiotics

    Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.

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