Continuous Manufacturing in Oral Solid Dosage
Continuous Manufacturing (CM) is a new technology trend in pharmaceutical tablet production which offers many benefits for economics and quality of the products – but challenges as well.
The material handling in CM lines requires specific excipient properties to achieve constant feeding performance, such as good flow and constant quality batch to batch. Excipients with optimal processing properties or excipients tailored for CM often allow to reduce the number of formulation components and, as a result, the number of feeding stations needed. Depending on the selected CM process, direct compressible materials, or materials compatible with twin screw granulation may be needed.
Our portfolio of excipients optimized for excellent performance in solid dose manufacturing processes, suitable for CM, includes:
- Parteck® LM self-lubricating filler/binder for all tableting processes and suitable for batch and continuous manufacturing processes.
- Parteck® M mannitol suitable for direct compression, dry granulation, and wet granulation, including twin screw granulation.
- Parteck® ODT excipient system for fast release and orally disintegrating dosage forms.
- Parteck® SRP 80 excipient designed for direct compression, enabling controlled release dosage forms.
- Polyvinyl alcohol 4-88 and particle-optimized quality Parteck® MXP 4-88 polymer as effective binders in continuous twin screw granulation.
All supported by the Emprove® Program with comprehensive documentation to speed up your way to the market. Whenever applicable, our products are compliant with the major pharmacopeias.
Self-Lubricated Filler-Binder Excipient System for Tableting
Excellent flow properties, consistent dosing, and robust, constant mixing times in continuous and batch processes. Two grades targeting different API dose and lubrication needs.
Advanced Mannitol for all Tableting Technologies
Particle-optimized mannitol for excellent performance in tableting and rapid release. Two grades available to serve your specific needs in direct compression, wet granulation, roller compaction, and CM approaches such as twin-screw granulation.
Directly Compressible Excipient for ODTs
Produce top quality, rapid acting tablets more cost effectively than ever. Robust tablets, rapid disintegration, excellent mouthfeel combined with superior performance in direct compression and continuous manufacturing.
Sustained-Release Solid Dose Formulations
Reliable sustained drug delivery with our functional, polyvinyl alcohol (PVA)-based excipient: suitable for direct compression, reduced risk for dose dumping, robust batch-to-batch consistency ideal for continuous manufacturing.
Related Product Resources
- Download: Formulation Handbook
In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- Brochure: Parteck® LM Excipient System Reduce Complexity in Your Formulation and Optimize Results
Discover the one step solution: lubricant, filler and binder. Perfect dosing and acceleration of your manufacturing process in batch or continuous manufacturing with Parteck® LM.
Related Webinars
In this webinar, you will learn about the key issues in continuous manufacturing concerning excipients and how to address them.
In this webinar, you will learn about the challenging issues of continuous manufacturing, its benefits, and how to address the challenges using excipients.
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