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Merck
CN

SRE0066

盐酸胍溶液，6M

别名:

盐酸氨基甲脒, 盐酸胍, 胍盐酸盐

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NACRES:
NA.25
UNSPSC Code:
12352209

主要文件

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form

liquid

concentration

6 M

Quality Level

500

impurities

<100 cfu/mL Bioburden

color

colorless

pH

4.5—5.5

density

1.1 —1.3  g/cm3

application(s)

diagnostic assay manufacturing

storage temp.

room temp

相关类别

Application

盐酸胍常用作变性剂，因为它能使氨基酸残基间氢键断裂。通过断开这些键，蛋白质的 3D 构象被展开，蛋白质的水溶性大大增加。一旦变性，可通过各种程序轻松还原、修饰或分析蛋白质。样品的进一步处理可以使蛋白质通过其他常见的蛋白质分析方法进行分析，包括质谱、电泳和酶消化。
盐酸胍通常也用于 RNA 的分离、球状蛋白质的变性和蛋白质复性研究。也可用于促进胰蛋白酶肽的生成，用于复杂蛋白样品的分析。

Physical form

本品为即用型 6 M 盐酸胍溶液。6 M 盐酸胍溶液可用作储备液，制备以下溶液： 适当降低浓度。

注：如果 6 M 缓冲液中存在沉淀，则将瓶加热至 37°C，混合直至完全溶解后使用。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000439783
0000439783
0000444673
0000444673
0000458838

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Jun-Yi Zhu et al.
Autophagy, 17(10), 3160-3174 (2021-01-07)
We investigated in larval and adult Drosophila models whether loss of the mitochondrial chaperone Hsc70-5 is sufficient to cause pathological alterations commonly observed in Parkinson disease. At affected larval neuromuscular junctions, no effects on terminal size, bouton size or number
Georgios I Laliotis et al.
Nature communications, 12(1), 4624-4624 (2021-08-01)
AKT-phosphorylated IWS1 regulates alternative RNA splicing via a pathway that is active in lung cancer. RNA-seq studies in lung adenocarcinoma cells lacking phosphorylated IWS1, identified a exon 2-deficient U2AF2 splice variant. Here, we show that exon 2 inclusion in the
Kaamini M Dhanabalan et al.
Biomaterials science, 8(15), 4308-4321 (2020-07-01)
Osteoarthritis (OA) is a joint disease characterized by progressive damage of articular cartilage and the adjoining subchondral bone. Chondrocytes, the primary cells of the cartilage, have limited regenerative capacity and when they undergo stress due to trauma or with aging
Jingwen Yang et al.
Science signaling, 14(665) (2021-01-14)
Cranial neural crest cells (CNCCs) are a population of multipotent stem cells that give rise to craniofacial bone and cartilage during development. Bone morphogenetic protein (BMP) signaling and autophagy have been individually implicated in stem cell homeostasis. Mutations that cause
Yoshinori Aso et al.
eLife, 8 (2019-11-15)
Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel

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