SAB5200020
Monoclonal Anti-MDC1 antibody produced in mouse
clone P2B11, 1 mg/mL, purified immunoglobulin
别名:
Anti-MDC1, P2B11, Anti-Nuclear factor with BRCT domains1, Anti-mediator of DNA damage checkpoint 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
P2B11, monoclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human, mouse, bovine, chimpanzee
Citations:
3
Technique(s):
indirect immunofluorescence: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Monoclonal Anti-MDC1 antibody produced in mouse, clone P2B11, 1 mg/mL, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
P2B11, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 184 kDa
species reactivity
human, mouse, bovine, chimpanzee
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... MDC1(240087)
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Biochem/physiol Actions
Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.
Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.
Immunogen
GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius
Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
MDC1 is a mediator of the mammalian DNA damage checkpoint
Stewart GS
Nature, 421, 961-966 (2003)
Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies.
Yamada Y
Oncotarget, 8, 38950-38961 (2017)
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Stucki M
Cell, 123, 1213-1226 (2005)
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