MDC1
mediator of DNA-damage checkpoint 1
别名:
NFBD1
物种:
Human MDC1 (9656), Mouse Mdc1 (240087), Rat Mdc1 (309595), chicken MDC1 (101664732), chicken MDC1 (101751335), domestic cat MDC1 (101095415), dog MDC1 (474829), sheep MDC1 (101107143), cow MDC1 (511168), Horse MDC1 (100055473) ...展开
UniProtKB ID:
基因ID:
- Human(9656) Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
- Mouse(240087) mediator of DNA damage checkpoint 1
- Rat(309595) mediator of DNA damage checkpoint 1
- chicken(101664732) mediator of DNA-damage checkpoint 1
- chicken(101751335) mediator of DNA-damage checkpoint 1
- domestic cat(101095415) mediator of DNA-damage checkpoint 1
- dog(474829) mediator of DNA-damage checkpoint 1
- sheep(101107143) mediator of DNA-damage checkpoint 1
- cow(511168) mediator of DNA-damage checkpoint 1
- Horse(100055473) mediator of DNA-damage checkpoint 1
- naked mole-rat(101702518) mediator of DNA-damage checkpoint 1
- domestic guinea pig(100721744) mediator of DNA-damage checkpoint 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-MDC1 antibody, Mouse monoclonal, clone MDC1-50, purified from hybridoma cell culture,
物种反应性
human, monkey
应用
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
ANTI-MDC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Rabbit anti-MDC1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
物种反应性
human
应用
immunoprecipitation (IP)
western blot
western blot
Monoclonal Anti-MDC1 antibody produced in mouse, clone P2B11, 1 mg/mL, purified immunoglobulin,
物种反应性
bovine, chimpanzee, human, mouse
应用
immunofluorescence
western blot
western blot
Anti-phospho-MDC1 (pSer513) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry