Anti-Chicken IgY (H+L), highly cross-adsorbed, CF^™ 633 antibody produced in donkey

Immunoglobulin Y is one of the antibodies produced in birds. It is generally related to mammalian IgG. However, IgY has different characteristics compared to mammalian IgG, for example, IgY does not bind with mammalian complements nor Rheumatoid factor, which are present in mammalian serum and anti-mammalian IgG antibodies, which often cross-react to IgG from different mammalian species, exhibit low cross-reactivity to IgY. These characteristics of IgY is beneficial when it is used as a biochemical/clinical reagent. Immunoglobulin Y present in chicken blood serum has the capability to pass across the follicular epithelium of the ovary and aggregate in the yolk during oogenesis. Structurally IgY and mammalian IgG differ in the heavy chain with the molecular weight of 68,000 and 50,000 respectively. Mammalian IgG has slightly higher stability compared to IgY.
CF^™ dyes are a series of highly water-soluble fluorescent dyes, with wavelength extended over the visible and near-infrared (IR) spectrum for labelling biomolecules, mainly proteins and nucleic acids. Primary structure of the CF^™ dyes is either cyanine dyes or rhodamine dyes. CF^™ 633 produce the brightest antibody conjugates among spectrally similar dyes when excited by the 633nm He-Ne laser or the 635nm red diode laser. The most important advantage of CF^™ 633 is its excellent photostability. Molecular weight of CF^™ 633 is ~820 and its absorption/emission maxima is at 630/650nm.

Binds all chicken IgYs (minimal cross-reaction with bovine, goat, guinea pig, syrian hamster, horse, human, mouse, rabbit, rat and sheep proteins)

chicken IgY (H+L)

Anti-Chicken IgY (H+L), highly cross-adsorbed, CF^™ 633 antibody produced in donkey has been used in immunofluorescence technique.

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Supplied in phosphate buffered saline with 0.05% sodium azide, 50% glycerol and 2 mg/mL bovine serum albumin.

Protect from light.

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