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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 162 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer1141)
基因信息
human ... WRN(7486)
一般描述
Werner syndrome, RecQ helicase-like (WRN) protein belongs to the RecQ family of DNA helicases. It has an adenosine triphosphate (ATP) binding site, one DExH helicase box, one exonuclease domain, and a nuclear localization signal. It is predominantly located in the nucleus. The WRN gene is located on human chromosome 8p12.
免疫原
The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141.
Immunogen Range: 1107-1156
Immunogen Range: 1107-1156
生化/生理作用
Werner syndrome, RecQ helicase-like (WRN) can interact with DNA polymerase δ (POLD1) and replication protein A (RPA) that are essential for the replication and repair of DNA. It also interacts with Ku protein which participates in double-strand DNA break repair. Mutation of the WRN gene results in Werner syndrome. WRN is a mortal target for cancer cells with microsatellite instability (MSI).
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Niek van Wietmarschen et al.
Nature, 586(7828), 292-298 (2020-10-02)
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair1-4. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading
WRN (Werner syndrome, RecQ helicase-like)
Amor-Gueret M
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2001)
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