WRN
Werner syndrome, RecQ helicase-like
别名:
RECQ3, RECQL2, RECQL3
物种:
Human WRN (7486), Mouse Wrn (22427), Rat Wrn (290806), naked mole-rat Wrn (101724469), domestic guinea pig Wrn (100719896), Domestic Rabbit WRN (100341925), sheep WRN (101106742), cow WRN (505061), domestic cat WRN (101095574), dog WRN (493997) ...展开
UniProtKB ID:
基因ID:
- Human(7486) Summary: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
- Mouse(22427) Werner syndrome homolog (human)
- Rat(290806) Werner syndrome
- naked mole-rat(101724469) Werner syndrome, RecQ helicase-like
- domestic guinea pig(100719896) Werner syndrome, RecQ helicase-like
- Domestic Rabbit(100341925) Werner syndrome, RecQ helicase-like
- sheep(101106742) Werner syndrome, RecQ helicase-like
- cow(505061) Werner syndrome, RecQ helicase-like
- domestic cat(101095574) Werner syndrome, RecQ helicase-like
- dog(493997) Werner syndrome, RecQ helicase-like
- chicken(422505) Werner syndrome
- Zebrafish(569495) Werner syndrome
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Antibodies
货号
说明
物种反应性
应用
抗-WRN抗体，小鼠单克隆 小鼠抗, clone 195C, purified from hybridoma cell culture,
物种反应性
human
应用
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1, clone 20A11.1, from mouse,
物种反应性
human
应用
western blot
Monoclonal Anti-WRN antibody produced in mouse, clone 3C11, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-WRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-WRN, (C-terminal) antibody produced in mouse, clone 2F7, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot