SAB4504153
Anti-phospho-CXCR4 (pSer339) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CD184, Anti-D2S201E, Anti-FB22, Anti-HM89, Anti-HSY3RR, Anti-LAP-3, Anti-LAP3, Anti-LCR1, Anti-LESTR, Anti-NPY3R, Anti-NPYR, Anti-NPYRL, Anti-NPYY3R, Anti-WHIM, Anti-WHIMS, Anti-WHIMS1
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所有图片(7)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 39 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer339)
基因信息
human ... CXCR4(7852)
一般描述
The CXC chemokine receptor 4 (CXCR4) is a G-protein coupled 7-transmembrane (TM) chemokine receptor. It is made up of 352 amino acids. CXCR4 is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells. This gene is located on human chromosome 2q22.1.
免疫原
The antiserum was produced against synthesized peptide derived from human CXCR4 around the phosphorylation site of Ser339.
Immunogen Range: 303-352
Immunogen Range: 303-352
应用
Anti-phospho-CXCR4 (pSer339) antibody has been used in immunohistochemical analysis.
生化/生理作用
The CXC chemokine receptor 4 (CXCR4) participates in the progression of the embryo, immune and inflammatory responses, modulation of hematopoiesis, human immunodeficiency virus infection and stimulation of angiogenesis. CXCR4 and its ligand, CXCL12 is involved in the synthesis of B-cell, myelopoiesis, integrin activation and chemotaxis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
Yang S, et al.
Development, dev-098145 (2013)
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
Chao Z, et al.
Chinese Journal of Cancer, 36(1), 80-80 (2017)
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.
Peng D, et al.
European Journal of Medicinal Chemistry, 149, 148-169 (2018)
Ben Hitchinson et al.
Science signaling, 11(552) (2018-10-18)
Repeated dosing of drugs targeting G protein-coupled receptors can stimulate antagonist tolerance, which reduces their efficacy; thus, strategies to avoid tolerance are needed. The efficacy of AMD3100, a competitive antagonist of the chemokine receptor CXCR4 that mobilizes leukemic blasts from
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Finkel T H, et al.
BMC Medical Genetics, 17(1), 24-24 (2016)
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