推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 33 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCND1(595)
一般描述
Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.
The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.
免疫原
The antiserum was produced against synthesized peptide derived from human Cyclin D1.
Immunogen Range: 246-295
Immunogen Range: 246-295
应用
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.
生化/生理作用
CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Lanza C
Cell Cycle, 15(10), 1363-1375 (2016)
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB
Cancer Research, 65(18), 8125-8133 (2005)
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Phan B
Oncotarget, 7(15), 19519-19530 (2016)
The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.
Xie M
Medicine, 96(42), 1-9 (2017)
Chris Lanza et al.
Cell cycle (Georgetown, Tex.), 15(10), 1363-1375 (2016-04-14)
Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in
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