CCND1
cyclin D1
别名:
BCL1, D11S287E, PRAD1, U21B31
物种:
Human CCND1 (595), Mouse Ccnd1 (12443), Rat Ccnd1 (58919), sheep CCND1 (100144763), Domestic Rabbit CCND1 (100009036), Zebrafish ccnd1 (30222), dog CCND1 (449028), cow CCND1 (524530), domestic guinea pig Ccnd1 (100729808), chicken CCND1 (396341) ...展开
UniProtKB ID:
基因ID:
- Human(595) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(12443) cyclin D1
- Rat(58919) cyclin D1
- sheep(100144763) cyclin D1
- Domestic Rabbit(100009036) cyclin D1
- Zebrafish(30222) cyclin D1
- dog(449028) cyclin D1
- cow(524530) cyclin D1
- domestic guinea pig(100729808) cyclin D1
- chicken(396341) cyclin D1
- domestic cat(100037407) cyclin D1
- naked mole-rat(101712621) cyclin D1
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Antibodies
货号
说明
物种反应性
应用
抗细胞周期素D抗体, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, primate
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Cyclin D1 Antibody, clone 1J9, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, monkey
应用
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Cyclin D1/2 Antibody, clone 5D4, clone 5D4, Upstate®, from mouse,
物种反应性
hamster, human, mouse, rat
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Cyclin D1 antibody, Rabbit monoclonal, clone SP4, recombinant, expressed in proprietary host, tissue culture supernatant,
物种反应性
bovine, chicken, dog, frog, human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Proteins
货号
说明
物种
CDK4/活性人细胞周期蛋白 D1, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
物种
human
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
CDK6/CyclinD1, active, His/GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human