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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
12 kDa
种属反应性
human
浓度
1.0 mg/mL
技术
immunohistochemistry: 1:50-1:100
同位素/亚型
IgG
登记号
NP_004086.1.
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pThr70)
基因信息
human ... EIF4EBP1(1978)
一般描述
The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is localized on human chromosome 8p12. It is a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E).
特异性
The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
免疫原
Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1.
生化/生理作用
EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) associates with eukaryotic translation initiation factor 4E (eIF4E), which is a multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of EIF4EBP1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA. This protein participates in cell proliferation, apoptosis, invasion and metastasis. EIF4EBP1 functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Gingras AC, et al.
Genes & Development, 13(11), 1422-1437 (1999)
EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma.
Cha YL, et al.
PLoS ONE, 10(2), e0117493-e0117493 (2015)
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
Boylan MO, et al.
Breast Cancer Research, 272(28), 17438-17443 (1997)
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.
Chao MW, et al.
Oncotarget, 6(27), 24092-24104 (2015)
Hui-Ying Huang et al.
Translational cancer research, 11(5), 1076-1088 (2022-06-17)
New and effective chemotherapy or targeted therapy strategies are needed against laryngeal squamous cell carcinoma (LSCC). We aimed to explore the antitumor effect of dual PI3K/mTOR inhibitor combined with autophagy suppression on LSCC and its underlying mechanism. Hep-2 and AMC-HN-8
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