推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~140 kDa
种属反应性
human, mouse, rat
浓度
1 mg/mL
技术
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(T-Q-S-F-S)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NOS3(4846)
一般描述
NOS3 (nitric oxide synthase 3) is located on human chromosome 7q36.
免疫原
Peptide sequence around aa. 1175-1179 (T-Q-S-F-S), according to the protein NOS3.
应用
Anti-NOS3 (Ab-1177) antibody has been used in western blotting.
生化/生理作用
Modifications in the NOS3 (nitric oxide synthase 3) gene leads to erectile dysfunction susceptibility, age of onset and severity. In heart, NOS3 helps in NO (nitric oxide) synthesis. It also controls vascular tone and blood pressure.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Endothelial nitric oxide synthase gene single nucleotide polymorphisms and the risk of hypertension: A meta-analysis involving 63,258 subjects
Xie X, et al.
Clinical and Experimental Hypertension, 39(2), 175-182 (2017)
Functional Variations in the NOS3 Gene Are Associated With Erectile Dysfunction Susceptibility, Age of Onset and Severity in a Han Chinese Population
Yang B, et al.
Journal of Sexual Medicine, 14(4), 551-557 (2017)
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
Ichinose F, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 286(3), H1070-H1075 (2004)
Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium
San Martin R and Sobrevia L
Placenta, 27(1), 1-10 (2006)
Zhi-Wei Zhou et al.
European journal of pharmacology, 697(1-3), 97-105 (2012-10-16)
Endothelial nitric oxide synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in many cardiovascular and metabolic diseases. Tanshinone IIA (Tan IIA), an active compound from Salvia miltiorrhiza, has been used to treat cardiovascular and metabolic diseases. However, the
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