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安全信息

SAB4300128

Sigma-Aldrich

Anti-phospho-NOS3 (pSer1177) antibody produced in rabbit

affinity isolated antibody

别名:

ECNOS, NOS, NOSIII, eNOS

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

predicted mol wt 133 kDa

种属反应性

mouse, rat, human

浓度

1 mg/mL

技术

western blot: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

phosphorylation (pSer1177)

基因信息

human ... NOS3(4846)

免疫原

Peptide sequence around phosphorylation site of serine 1177 (T-Q-S(p)-F-S), according to the protein NOS3.

应用

Recommended dilutions
Western Blot 1:500 - 1:1000

Optimal dilutions should be determined by the user.

生化/生理作用

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yuki Hirano et al.
Cardiovascular research, 113(10), 1208-1218 (2017-05-05)
Although surfactant protein-D (SP-D) is a pneumoprotein that is predominantly synthesized by type II epithelial cells in the lung, individuals with increased circulating levels of SP-D are at an elevated risk of mortality from ischemic heart disease. Whether SP-D contributes
Naoyuki Otani et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 41(11), 923-931 (2018-09-07)
This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed reactive hyperemia peripheral arterial tonometry using an EndoPAT 2000 device
Szabolcs Zahorán et al.
Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
Nitric oxide (NO) bioavailability is fundamental in the regulation of redox balance and functionality of the endothelium, especially in the case of the umbilical cord (UC), which has no innervation. The analysis of UC vessel-related complications could serve as a
Deok Hwa Nam et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 711-721 (2018-07-20)
Coordinated changes in signaling pathways and gene expression in hearts subjected to prolonged stress maintain cardiac function. Loss of steroid receptor coactivator-2 (SRC-2) results in a reversal to the fetal gene program and disrupts the response to pressure overload, accompanied
David C Reineke et al.
European journal of medical research, 20, 59-59 (2015-06-25)
Definitive fate of the coronary endothelium after implantation of a drug-eluting stent remains unclear, but evidence has accumulated that treatment with rapamycin-eluting stents impairs endothelial function in human coronary arteries. The aim of our study was to demonstrate this phenomenon

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