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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... SLC7A11(23657)
一般描述
Solute carrier family 7, membrane 11 (SLC7A11), a constituent of the cysteine-glutamate transporter, is located on human chromosome 4q28.31. It belongs to the system xc- light chain family. SLC7A11 gene codes for the cystine-glutamate antiporter Xct.
免疫原
Synthetic 19 amino acid peptide from N-terminus of human SLC7A11. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Marmoset (95%); Horse (89%); Rat, Dog, Hamster (84%).
应用
Anti-SLC7A11 antibody has been used in western blot analysis.
生化/生理作用
Solute carrier family 7, membrane 11 (SLC7A11) or xCT participates in glutathione homeostasis, that helps to guard the cells against oxidative stress. It is involved in the pathogenesis of malignant tumors. SLC7A11 is associated with triple negative breast cancer and glioblastoma (GBM).
特点和优势
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外形
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Yuchao G, et al.
Molecular Cell, 67(1), 128?138-128?138 (2017)
MiR?375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion.
Wu Y, et al.
Cancer Medicine, 6(7), 1686-1697 (2017)
SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma.
Ma Z, et al.
Oncology Reports, 38(5), 3019-3029 (2017)
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer.
Yajun L, et al.
Oncotarget, 8(68), 112530?112549-112530?112549 (2017)
Yadong Wu et al.
Cancer medicine, 6(7), 1686-1697 (2017-06-20)
We aimed to detect the functions of miR-375/SLC7A11 axis on oral squamous cell carcinoma (OSCC) cell proliferation and invasion. Expression levels of miR-375 and SLC7A11 in OSCC tissues and cells were measured with RT-qPCR and western blot. Targeting site was
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