推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
分子量
79 kDa
种属反应性
chicken, human, mouse
浓度
0.86 mg/mL
技术
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: 500-3000
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... HHIP(64399)
一般描述
The gene encoding HHIP (hedgehog interacting protein) is located on human chromosome 4 and encodes for a protein belonging to the hedgehog-interacting protein (HHIP) family.
免疫原
Recombinant fragment corresponding to a region within amino acids 263 and 554 of HHIP (Uniprot ID#Q96QV1)
应用
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
生化/生理作用
Hedgehog interacting protein (HHIP) is highly conserved and interacts with all the three HH family members namely SHH (sonic hh), IHH (indian hh) and DHH (desert hh). It is also a vertebrate-specific inhibitor of HH signaling. Single nucleotide polymorphisms in the HHIP gene are associated with increase in the risk of chronic obstructive pulmonary disease (COPD).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Warning
危险声明
危险分类
Aquatic Chronic 3 - Skin Sens. 1
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, et al.
Bosnian Journal of Basic Medical Sciences / Udruzenje Basicnih Mediciniskih Znanosti = Association of Basic Medical Sciences, 18(1), 8-8 (2018)
Xiaobo Zhou et al.
Genomics, 101(5), 263-272 (2013-03-06)
Hedgehog interacting protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify genes regulated by HHIP, we performed gene expression microarray analysis in
Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.
Bo Wang et al.
Gene, 531(1), 101-105 (2013-09-03)
The hedgehog signaling pathway plays an important role in lung morphogenesis and cellular responses to lung injury. Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated the associations between HHIP polymorphisms and chronic obstructive pulmonary disease (COPD) and in
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