product name
链脲菌素, ≥75% α-anomer basis, ≥98% (HPLC), powder
质量水平
检测方案
≥75% α-anomer basis
≥98% (HPLC)
形式
powder
颜色
white to light yellow
mp
121 °C (dec.) (lit.)
抗生素抗菌谱
neoplastics
作用机制
DNA synthesis | interferes
储存温度
−20°C
SMILES字符串
CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
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一般描述
在细胞培养基中具有约19分钟的生物半衰期。它是强效的甲基化试剂，可在体外与DNA作用生成甲基化嘌呤。链脲佐菌素对哺乳动物中产胰岛素的胰岛β细胞具有特别的毒性，因此可影响葡萄糖代谢。它还是针对革兰氏阴性菌的有效抗生素。它抑制微生物和哺乳动物细胞的DNA合成，机制是对DNA链进行甲基化和交联反应，影响哺乳动物细胞周期的所有阶段。链脲佐菌素具有致突变和致癌作用，并可能对人有致畸作用。对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。
应用
生化/生理作用
其他说明
警示用语：
Warning
危险声明
危险分类
Carc. 2 - Flam. Sol. 2 - Muta. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How should I store Product S0130, Streptozocin, upon receipt?
Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.
How do I store solutions of Product S0130, Streptozocin?
Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.
What is the half-life of Product S0130, Streptozocin?
Streptozocin has a reported half life of 15 to 30 minutes.
How can I make a solution of Product S0130, Streptozocin?
This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.
Can Product S0130, Streptozocin, be used to induce diabetes? What concentration should be used?
We do not test Streptozocin, Product No. S0130 for biological activity. We recommend screening lots for biological activity. An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Ask a Scientist here.
diabetes studies and muscle hypertrophy models?
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