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药品控制
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
溶解性
H2O: slightly soluble
dilute aqueous acid: soluble
ethanol: soluble
SMILES字符串
Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
InChI
1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1
InChI key
NAHATSPWSULUAA-HWXFZQNOSA-N
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生化/生理作用
μ 受体拮抗剂、κ 受体部分激动剂和 σ 受体激动剂，但是与 σ 受体的亲和力不高
D M Sherman et al.
Eksperimental'naia i klinicheskaia farmakologiia, 61(1), 25-29 (1998-05-12)
Experiments on 81 rabbits showed that intravenous infusion of naloxone and nalorphine in different periods of hemorrhagic shock promoted the death of animals. It is concluded that in hypoxia only the antagonistic activity of the drugs is manifested as total
Andrew C Barrett et al.
Psychopharmacology, 160(2), 170-181 (2002-03-05)
Recent studies indicate that sex and rodent strain are determinants of sensitivity to opioid-induced antinociception. The present study examined the influence of sex and rat strain on kappa opioid-induced antinociception using a series of kappa opioids that vary in their
L A Dykstra et al.
Psychopharmacology, 130(1), 14-27 (1997-03-01)
Although a large and rich body of data is available regarding the discriminative stimulus effects of opioids in laboratory animals and human subjects, it has been difficult to reconcile the data obtained from these two different sources. Therefore, the purpose
D S Kim et al.
FEBS letters, 376(1-2), 11-14 (1995-11-27)
Exposure of neuronal cells to the chronic presence of opiates leads to a complex series of biochemical events which reflect the changes that result in tolerance and dependence in animals. To achieve a better understanding of the molecular mechanisms underlying
S D Grabus et al.
Pharmacology, biochemistry, and behavior, 63(3), 481-488 (1999-07-27)
Rats trained to discriminate the mu agonists fentanyl or morphine from their respective vehicles generalize to the partial mu agonist nalorphine incompletely and inconsistently. Any number of factors may influence the generalization patterns obtained, one of which being the specific
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