InChI key
NAHATSPWSULUAA-HWXFZQNOSA-N
InChI
1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1
SMILES string
Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: slightly soluble, dilute aqueous acid: soluble, ethanol: soluble
Biochem/physiol Actions
μ 受体拮抗剂、κ 受体部分激动剂和 σ 受体激动剂，但是与 σ 受体的亲和力不高
C Y Cheng et al.
Bioorganic & medicinal chemistry, 4(1), 73-80 (1996-01-01)
N-Cubylmethylnormorphine (1) and N-cubylmethylnoroxymorphone (2) have been synthesized and found to be more potent ligands at the mu and kappa opioid receptors than morphine and oxymorphone respectively. In the guinea-pig ileum preparation, compounds 1 and 2 were characterized as opioid
M R Bouw et al.
Pharmaceutical research, 15(11), 1673-1679 (1998-12-02)
To investigate the performance of two alternative retrodialysis recovery methods and to describe the influence of different recoveries on the reliability in estimating unbound extracellular concentrations of morphine. Unbound concentrations of morphine in striatum and in blood were determined by
D Morgan et al.
Psychopharmacology, 140(1), 20-28 (1998-12-23)
The purpose of the present study was to determine the relative intrinsic efficacy of various opioids using the irreversible mu opioid antagonist beta-funaltrexamine (betaFNA). To this end, pigeons were trained to discriminate 3.0 (n=6) or 1.8 (n=1) mg/kg morphine from
C D King et al.
Archives of biochemistry and biophysics, 332(1), 92-100 (1996-08-01)
Rat and human UDP-glucuronosyltransferase (UGT) 1.1 share > 70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed
David A White et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 374-382 (2005-04-22)
The discriminative stimulus effects of acute morphine followed by naltrexone have been described previously in nonhuman primates. The purposes of this study were to 1) extend the pharmacological characterization of the discrimination by testing mu-opioid agonists other than morphine and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持