InChI key
NAHATSPWSULUAA-HWXFZQNOSA-N
InChI
1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1
SMILES string
Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: slightly soluble, dilute aqueous acid: soluble, ethanol: soluble
Biochem/physiol Actions
μ 受体拮抗剂、κ 受体部分激动剂和 σ 受体激动剂，但是与 σ 受体的亲和力不高
C Y Cheng et al.
Bioorganic & medicinal chemistry, 4(1), 73-80 (1996-01-01)
N-Cubylmethylnormorphine (1) and N-cubylmethylnoroxymorphone (2) have been synthesized and found to be more potent ligands at the mu and kappa opioid receptors than morphine and oxymorphone respectively. In the guinea-pig ileum preparation, compounds 1 and 2 were characterized as opioid
M R Bouw et al.
Pharmaceutical research, 15(11), 1673-1679 (1998-12-02)
To investigate the performance of two alternative retrodialysis recovery methods and to describe the influence of different recoveries on the reliability in estimating unbound extracellular concentrations of morphine. Unbound concentrations of morphine in striatum and in blood were determined by
D M Sherman et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (2)(2), 11-14 (2004-06-24)
Acute experiments on 75 adult rabbits were made to study action of intravenous injections of naloxone (0.1 mg/kg), nalorphine (0.5 and 2.0 mg/kg) and dalargin (0.1 mg/kg) in early and late periods of irreversible shock caused by combination of non-shockogenic
R Xie et al.
Pharmaceutical research, 15(4), 570-575 (1998-05-20)
The purpose of the study was to investigate the distribution of codeine across the blood-brain barrier (BBB) in rats by microdialysis (MD). Rats were administered intravenous infusion of codeine in doses of (1) 10 mg/kg, (2) 20 mg/kg for 10
C D King et al.
Archives of biochemistry and biophysics, 332(1), 92-100 (1996-08-01)
Rat and human UDP-glucuronosyltransferase (UGT) 1.1 share > 70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed
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