InChI key
NAHATSPWSULUAA-HWXFZQNOSA-N
InChI
1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1
SMILES string
Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
H2O: slightly soluble
dilute aqueous acid: soluble
ethanol: soluble
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Biochem/physiol Actions
μ 受体拮抗剂、κ 受体部分激动剂和 σ 受体激动剂，但是与 σ 受体的亲和力不高
L A Dykstra et al.
Psychopharmacology, 130(1), 14-27 (1997-03-01)
Although a large and rich body of data is available regarding the discriminative stimulus effects of opioids in laboratory animals and human subjects, it has been difficult to reconcile the data obtained from these two different sources. Therefore, the purpose
P Van Eenoo et al.
Forensic science international, 164(2-3), 159-163 (2006-02-02)
A simple, fast and sensitive method for the quantitative determination of strychnine residues in urine has been developed and validated. The method consists of a liquid-liquid extraction step with ethyl acetate at pH 9.2, followed by LC-MS/MS in positive atmospheric
Andrew C Barrett et al.
Psychopharmacology, 160(2), 170-181 (2002-03-05)
Recent studies indicate that sex and rodent strain are determinants of sensitivity to opioid-induced antinociception. The present study examined the influence of sex and rat strain on kappa opioid-induced antinociception using a series of kappa opioids that vary in their
D S Kim et al.
FEBS letters, 376(1-2), 11-14 (1995-11-27)
Exposure of neuronal cells to the chronic presence of opiates leads to a complex series of biochemical events which reflect the changes that result in tolerance and dependence in animals. To achieve a better understanding of the molecular mechanisms underlying
S D Grabus et al.
Pharmacology, biochemistry, and behavior, 63(3), 481-488 (1999-07-27)
Rats trained to discriminate the mu agonists fentanyl or morphine from their respective vehicles generalize to the partial mu agonist nalorphine incompletely and inconsistently. Any number of factors may influence the generalization patterns obtained, one of which being the specific
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