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C-008

Supelco

可卡因标准液 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C17H21NO4
CAS号:
50-36-2
分子量:
303.35
MDL编号:
MFCD00056906
UNSPSC代码:
41116107
PubChem化学物质编号:
329774761
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)

浓度

1.0 mg/mL in acetonitrile

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

包装形式

single component solution

储存温度

−20°C

SMILES字符串

COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI

1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1

InChI key

ZPUCINDJVBIVPJ-LJISPDSOSA-N

一般描述

经认证的加标溶液®适用于法医分析、尿液药物测试或临床毒理学的LC/MS或GC/MS试验应用。可卡因是从古柯植物的叶子中提取的莨菪烷类生物碱和非法药物。这种流行的消遣性药物是中枢神经系统的强大兴奋剂，具有食欲抑制剂和局部麻醉特性。

应用


  • 科研用高纯度盐酸可卡因：研究人员开发了一种使用磁性纳米颗粒对尸检血样中的可卡因及其代谢物进行法医检测的创新分析方法，该研究强调了其在复杂生物基质中检测和定量测定可卡因的准确性（de Souza Schwarz et al., 2024）。


法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

35.6 °F - closed cup

闪点(°C)

2 °C - closed cup

法规信息

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历史批次信息供参考:

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Emmanuelle Jordi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9511-9516 (2013-05-22)
Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in striatal neurons. These changes are thought to participate in physiological memory mechanisms and to be critical for long-term behavioral
Liu Xue et al.
The Biochemical journal, 453(3), 447-454 (2013-07-16)
Cocaine is a widely abused drug without an FDA (Food and Drug Administration)-approved medication. It has been recognized that an ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway
An indirect resilience to addiction.
Marina R Picciotto
Nature neuroscience, 16(5), 521-523 (2013-04-27)
Xiaoqing Cai et al.
Journal of medicinal chemistry, 56(9), 3701-3709 (2013-05-01)
Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus terminating both psychoactive effects and drug toxicity. Herein, we report our efforts
Scott J Moeller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10027-10036 (2013-06-14)
Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with homozygote carriers of the 10R-allele) show heightened reactivity to drug-related reinforcement in addiction. Here, using
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