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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
off-white
mp
127-128 °C
溶解性
DMSO: >5 mg/mL
H2O: insoluble
SMILES字符串
CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O
InChI
1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChI key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
基因信息
human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743)
mouse ... Ptgs2(19225)
应用
NS-398作为环氧化酶2(COX2)抑制剂,已用于研究其:
- 对斑马鱼胚胎心率的作用
- 对大鼠心肌细胞凋亡和缺氧/复氧的作用
- 对大鼠脂多糖(LPS)诱导厌食的作用
生化/生理作用
NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。
选择性环加氧酶-2(COX-2)抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种:
Experimental neurology, 234(2), 466-481 (2012-02-09)
Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn. Peripheral nerve injury
Placenta, 68, 44-51 (2018-07-30)
Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth factor-β1 (TGF-β1) have been shown to
General pharmacology, 24(1), 105-110 (1993-01-01)
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac.
Clinical science (London, England : 1979), 132(13), 1453-1470 (2018-05-10)
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbors axons emanating to the kidney.
Cells, 8(7) (2019-06-30)
The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6
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