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Merck
CN

N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

别名:

N-[2-(环己氧基)-4-硝基苯基]甲磺酰胺

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About This Item

经验公式(希尔记法):
C13H18N2O5S
分子量:
314.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

solid

颜色

off-white

mp

127-128 °C

溶解性

DMSO: >5 mg/mL
H2O: insoluble

SMILES字符串

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

应用

NS-398作为环氧化酶2(COX2)抑制剂,已用于研究其:
  • 对斑马鱼胚胎心率的作用
  • 对大鼠心肌细胞凋亡和缺氧/复氧的作用
  • 对大鼠脂多糖(LPS)诱导厌食的作用

生化/生理作用

NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。
选择性环加氧酶-2(COX-2)抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn. Peripheral nerve injury

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